ArticleBrain injury2026
Brain creatine concentrations are associated with sex and symptom severity after concussion: a cross-sectional MR-spectroscopy investigation of adolescents with concussion.
David R Howell, Carson L Keeter, Ved Hatolkar, Katherine L Smulligan, Aubrey M Armento, Jessie R Oldham, Julie Wilson, Katie Breedlove, Alexander P Lin
Abstract read
In one paragraphArticle in Brain injury, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
David R HowellDepartment of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0002-2955-0191 Carson L KeeterDepartment of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Ved HatolkarCenter for Clinical Spectroscopy and Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Katherine L SmulliganDepartment of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Aubrey M ArmentoDepartment of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Jessie R OldhamDepartment of Physical Medicine and Rehabilitation, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Julie WilsonDepartment of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Katie BreedloveCenter for Clinical Spectroscopy and Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Alexander P LinCenter for Clinical Spectroscopy and Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Funding
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1MColorado Clinical and Translational Sciences Institute (CCTSI)UM1TR004399 · NCATS · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS, RONALD J. SOKOL · 2023 to 2026
$30.7MSGM Administrative SupplementR01NS115957 · NINDS · RBHS-SCHOOL/ HEALTH RELATED PROFESSIONS · PI ESOPENKO, CARRIE LYNN, HILLARY, FRANK GERARD · 2021 to 2025
$3.4MModulating Exercise Dosage to Improve Concussion Rehabilitation: A Randomized Clinical TrialR01HD108133 · NICHD · UNIVERSITY OF COLORADO DENVER · PI David R. Howell · 2022 to 2026
$3.3MCTSA K12 Program at University of Colorado DenverK12TR004412 · NCATS · UNIVERSITY OF COLORADO DENVER · PI ELLEN L BURNHAM · 2024 to 2026
$3.2MSex Differences in Brain Structure and Function After Sports-Related ConcussionR01NS100952 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI KOERTE, INGA KATHARINA · 2017 to 2022
$2.9MA novel smartphone-based tool to quantify dual-task gait performance for concussion assessmentR43NS108823 · NINDS · CONTROL ONE, LLC · PI LUGADE, VIPUL · 2019 to 2019
$150k2022 Pediatric Research in Sports Medicine (PRiSM) Annual ConferenceR13AR080451 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI HOWELL, DAVID R. · 2022 to 2024
$45kNCATS NIH HHS K12 TR004412NCATS NIH HHS UL1 TR002535NCATS NIH HHS UM1 TR004399NIAMS NIH HHS R13 AR080451NICHD NIH HHS R01 HD108133NINDS NIH HHS R01 NS100952NINDS NIH HHS R01 NS115957NINDS NIH HHS R43 NS108823
6 · The paper itselfAbstract
backgroundPost-concussion brain energy is important for recovery, and measuring energy markers with individual characteristics may clarify recovery mechanisms. PURPOSE: To examine the association between magnetic resonance spectroscopy (MRS)-based brain energy measures (creatine concentration) with sex and patient-reported outcomes after concussion.
methodsWe evaluated adolescents with a concussion ≤3 weeks post-injury. Participants underwent 3T short-echo single-voxel MRS using a 32-channel head coil. Point-resolved spectroscopy (TR = 2000 ms, TE = 30 ms, voxel size = 20 × 20 × 20 mm
results
conclusionPost-concussion sex differences in creatine concentrations were detected, as higher creatine levels moderately correlated with patient-reported outcomes. Creatine may reflect altered energy dynamics in the brain. The absence of a non-injured control group limits determination of whether these differences are concussion-specific or reflective of baseline physiology.
Indexed as
BrainBrain ConcussionCreatineAdolescentCross-Sectional StudiesFemaleHumansMagnetic Resonance SpectroscopyMalePost-Concussion SyndromeSeverity of Illness IndexSex FactorsCreatineadolescentadvanced neuroimagingenergymild traumatic brain injurySex difference
Identifiers
PMID41504207
PMCPMC13383317
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