ArticleJournal of virology2026
Salvianolic acid A exerts antiviral effects by targeting the S protein, a virulence factor of porcine epidemic diarrhea virus.
Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Cross-Talk Between Pyroptosis and Ferroptosis Promotes Intestinal Inflammation and Barrier Failure During PEDV Infection.Biomolecules · 2026Article
- Genetic Diversity, Recombination, and Pathogenicity of Porcine Epidemic Diarrhea Virus Strains Circulating in China During 2023-2024.Transboundary and emerging diseases · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porcine epidemic diarrhea virus (PEDV), a member of the Coronaviridae family, infects the small intestinal epithelial cells of pigs, causing porcine epidemic diarrhea (PED), which is particularly severe in young piglets. Owing to its strong immunogenicity, the S1 subunit of the PEDV spike (S) protein mediates viral invasion by recognizing host cell receptors and inducing neutralizing antibodies. However, effective antiviral drugs against PEDV are lacking, and current control measures are limited. In this study, the truncated S1 protein was expressed and used in surface plasmon resonance screening of 416 natural compounds. Salvianolic acid A (SalA) exhibited the strongest antiviral activity against PEDV, with a dissociation constant KD of 4.54 × 10⁻⁷ M. Molecular docking revealed multiple hydrogen bonds between SalA and key amino acid residues of the S1 protein. IMPORTANCE: Porcine epidemic diarrhea virus (PEDV) causes severe diarrhea and high mortality in piglets, resulting in substantial economic losses to the global swine industry. However, effective antiviral therapeutics are still lacking. In this study, salvianolic acid A (SalA), a natural polyphenolic compound derived from
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