Complete Genome Sequencing of Streptomyces sp. Qhu-M197 Isolated from Alpine Meadows in the Qinghai-Tibetan Plateau Uncovers Biosynthetic Gene Clusters Encoding Bioactive Natural Products.

Xin Xiang, Jiakai Fan, Xingyu Liu, Guangzhi Li, Chenghang Sun, Benyin Zhang

Abstract read

In one paragraph

Article in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xin XiangState Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, 810016, Qinghai, China.

Jiakai FanCollege of Eco-Environmental Engineering, Qinghai University, Xining, 810016, Qinghai, China.

Xingyu LiuCollege of Eco-Environmental Engineering, Qinghai University, Xining, 810016, Qinghai, China.

Guangzhi LiCollege of Eco-Environmental Engineering, Qinghai University, Xining, 810016, Qinghai, China.

Chenghang SunState Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, 810016, Qinghai, China. sunchenghang@imb.pumc.edu.cn.

Benyin ZhangState Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, 810016, Qinghai, China. benyinzhang@qhu.edu.cn.

Funding

Guiding Funds of Central Government for Supporting the Development of the Local Science and Technology, Qinghai Province 2024ZY007National Natural Science Foundation of China 31960642Open Project of State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University 2023-KF-06

6 · The paper itself

Abstract

Streptomyces spp. is a crucial source for the drug discovery and development, especially those from extreme environments. The complete genome was sequenced to uncover the biosynthetic potential of the strain Qhu-M197 producing mithramycin isolated from the alpine meadow of the Qinghai-Tibetan Plateau. The results revealed that the genome consists of one linear chromosome and two plasmids with the size of 9.12 megabases (Mb) and the guanine-cytosine (G + C) content of 71.52%. The phylogenetic analyses of 16S rRNA gene and genome of strain Qhu-M197 suggested the strain belonged to Streptomyces genus, and the closest phylogenetic relationship between the strain Qhu-M197 and S. phaeoluteigriseus DSM 41896

Indexed as

Biological ProductsGenome, BacterialMultigene FamilyStreptomycesWhole Genome SequencingBase CompositionPhylogenyRNA, Ribosomal, 16STibetBiological ProductsRNA, Ribosomal, 16SBiosynthetic gene clustersGenome sequencingNatural productsPhylogenetic analysisStreptomyces

Identifiers

PMID41504849

DOI10.3390/antibiotics8030133

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.