ArticleClinical research in cardiology : official journal of the German Cardiac Society2026
Microvascular dysfunction and heart failure with preserved ejection fraction.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimThe impact of coronary microvascular dysfunction (CMD) on parameters of systolic and diastolic function, particularly in patients with heart failure and preserved ejection fraction (HFpEF), is poorly understood. Although these conditions often overlap, their combined impact on parameters of systolic and diastolic function remains unexplored.
methodsConsecutive patients undergoing invasive CMD assessment were enrolled. Systolic function was assessed by global longitudinal strain (GLS), diastolic function by E/E', left atrial reservoir strain (LARS), and non-invasive single-beat pressure-volume relationship stiffness constant (β) estimation.
resultsOf 145 patients, 72 (49.7%) had CMD, 35 (24%) HFpEF, and 23 (16%) both conditions. HFpEF was twice as prevalent in CMD patients as compared to patients without CMD (32% vs. 16%, p = 0.034). Both CMD was associated with parameters of both diastolic (E/E' β = 0.29, p < 0.001, LV stiffness constant β = 0.23; p = 0.006, and LARS β = -0.21, p = 0.02) and systolic function (GLS β = 0.31, p < 0.001). The presence of CMD was associated with an impairment in LV stiffness both in patients with and without HFpEF (p for interaction = 0.044).
conclusionHFpEF is highly prevalent in patients with CMD, and CMD is associated with both systolic and diastolic dysfunction. In patients with HFpEF, an additional worsening of diastolic function is observed.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.