ArticleCerebellum (London, England)2026
Altered Glymphatic Network in Spinocerebellar Ataxia: a Multimodal MRI Study Within a Structure-Environment-Function Framework.
Article in Cerebellum (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Glymphatic dysfunction in cerebellar neurodegeneration: mechanistic insights and emerging clinical implications.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study characterizes in vivo glymphatic system alterations in spinocerebellar ataxia (SCA) using a structure-environment-function multimodal MRI framework and explores subtype-specific signatures and longitudinal progression. Twenty genetically confirmed SCA patients (SCA1 = 1, SCA2 = 11, SCA3 = 6, SCA7 = 2) and 23 matched healthy controls underwent MRI across two scanners. The framework included structural (perivascular space volume fraction, pPVS; choroid plexus volume, CPV), environmental (free water, FW), functional (DTI-ALPS index), and microstructural (fractional anisotropy, FA) metrics. Data were harmonized across sites. Cross-sectional, subtype, and longitudinal analyses were performed. SCA patients demonstrated significantly enlarged subcortical pPVS, elevated FW, and reduced FA compared to controls (all surviving FDR correction, q = 0.05), while CPV/rCPV showed non-significant trends and the ALPS index showed no group difference. Subtype analyses revealed higher white matter and total pPVS in SCA3 versus SCA2 (surviving FDR correction), but FW differences did not survive correction. Longitudinally, the SCA2 subset exhibited significant FA decline over time (p < 0.001), with robust group effects on FW and WM pPVS. Within a structure-environment-function framework, SCA exhibits prominent glymphatic-related abnormalities in perivascular and interstitial compartments, with preserved ALPS index. Distinct imaging signatures of SCA2 and SCA3 suggest divergent pathophysiologies. FW and FA emerge as promising complementary biomarkers for monitoring disease burden and progression in future trials.
Indexed as
Identifiers
41504997What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.