ArticleJournal of endocrinological investigation2026
Oral health and salivary inflammatory markers in children and adolescents with type 1 diabetes: A cross-sectional study.
Article in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Oral microbiome alterations in individuals with type 1 diabetes: a systematic review.Clinical oral investigations · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the oral health status of children and young adults with type 1 diabetes (T1D) compared with healthy controls (HC), and its association with clinical parameters and salivary inflammatory markers.
methodsSeventy-two subjects with T1D and 86 HCs underwent a clinical oral examination. Salivary cytokines were measured using multiplex immunoassays. Differences between oral conditions, clinical parameters and cytokines were tested and mediation models were used to evaluate the role of T1D and HbA1c.
resultsT1D subjects showed significantly higher frequencies of caries (67% vs. 28.5%) and gingivitis (76% vs. 42%) compared with HC (p < 0.001), independently by oral hygiene habits. In T1D, the presence of caries and gingivitis is associated with unfavourable clinical outcomes, including higher HbA1c, triglycerides, and urinary creatinine (p-value < 0.05). Salivary cytokine profile differed according to oral condition: caries was associated with reduced IL-4, IL-10, and IFN-γ; gingivitis with elevated IL-1Ra and RANTES; and both conditions with increased IL-1β (p-value < 0.05). Mediation analyses revealed no significant influence of HbA1c.
conclusionChildren and young adults with T1D show a higher prevalence of oral diseases and distinct inflammatory profile, regardless of metabolic status. These findings call for routine integration of oral assessment in T1D management.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.