ArticleProceedings of the National Academy of Sciences of the United States of America2026
Elucidating cooperative genetic events in DCIS progression in mutant
Rhiannon L Morrissey, Joy M McDaniel, Gilda P Chau, Xiaoping Su, Mitheera V, Vidhi Chandra, Beverly R E A Dixon, Adel K El-Naggar, Alastair M Thompson, Guillermina Lozano
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Rhiannon L MorrisseyThe University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX 77030.
Joy M McDanielDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Gilda P ChauDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.ORCID 0000-0002-7907-3290
Xiaoping SuDepartment of Biostatistics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Mitheera VThe University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX 77030.
Vidhi ChandraDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Beverly R E A DixonDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Adel K El-NaggarDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Alastair M ThompsonDivision of Surgical Oncology, Department of Surgery, Baylor College of Medicine, Houston, TX 77030.
Guillermina LozanoThe University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX 77030.ORCID 0000-0001-8985-4886
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
Role of p53 Missense Mutations on Tumorigenesis in VivoR01CA082577 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LOZANO, GUILLERMINA · 1999 to 2024
$7.3M
Upgrading an existing NIKON A1-confocal with LUNV Laser Launch and DU-G detectorS10OD024976 · OD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LOZANO, GUILLERMINA · 2018 to 2018
$202k
Cancer Prevention and Research Institute of Texas (CPRIT) RP180313HHS | NIH | National Cancer Institute (NCI) 5F31CA246917HHS | NIH | National Cancer Institute (NCI) 5F32CA232463HHS | NIH (NIH) CA82577NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA082577NIH HHS S10 OD024976
6 · The paper itself
Abstract
Ductal carcinoma in situ (DCIS) is a precursor mammary lesion characterized by abnormal epithelial cells in mammary ducts that remain confined to the luminal space. Not all DCIS becomes invasive, and no strategy currently exists in patients to stratify indolent DCIS from DCIS at risk of progression. Several studies of human DCIS and breast cancer suggest that
Indexed as
Breast NeoplasmsCarcinoma, Intraductal, NoninfiltratingTumor Suppressor Protein p53AnimalsDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMembrane ProteinsMiceMutationMembrane ProteinsTrp53 protein, mouseTumor Suppressor Protein p53breast cancerDCISmouse modelsmutant p53
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Elucidating cooperative genetic events in DCIS progression in mutant · full record | Socratic