ArticleNature communications2026
Chlorella-derived extracellular vesicle-based nanogels suppress cGAS-STING for treatment of radiation-induced lung injury.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- 3D-printed implantable CAR-macrophages for post-surgery cancer immunotherapy.Journal of nanobiotechnology · 2026Article
- Garlic-derived exosome-like nanovesicle core-shell platform for sequential infection treatment and tissue repair.Journal of nanobiotechnology · 2026Article
- The potential role of lily polysaccharide in mitigating radiation-induced pneumonitis via the gut-lung axis: a comprehensive review.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiation-induced lung injury (RILI) represents a critical complication associated with radiation exposure, requiring targeted treatment strategies in clinical practice. Here, we pioneered the extraction of extracellular vesicles (EVs) from Chlorella and innovatively developed a multifunctional nanogel platform (RU.521-EVs NPs) by combining them with the cGAS inhibitor RU.521. The Chlorella-derived EVs possess a naturally high abundance of antioxidant enzymes (e.g., SOD2, CAT) and anti-inflammatory lipids (e.g., linolenic acid). RU.521-EVs NPs could synergistically inhibit excessive activation of the cGAS-STING pathway, and significantly reduce the secretion of pro-inflammatory factors. In the RILI mouse model, the nanogel demonstrated significant anti-inflammatory and anti-fibrosis activity, with no observed systemic toxicity. Their biological safety, cost-effectiveness, and multifaceted anti-radiation mechanisms of nanogels make them particularly beneficial in contexts such as medical radiation exposure, providing a strategy for the clinical translation of RILI that emphasizes both safety and long-term efficacy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.