Evidence map›Paper›PMID 41507193›Full record

ArticleNature communications2026

TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strength.

Martina Spiga, Alessia Potenza, Zulma Magnani, Stefano Beretta, Barbara Camisa, Laura Conte, Alessia Airaghi, Neda Mohammadi, Laura Perani, Claudio Doglioni and 28 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Martina Spiga *Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0003-0038-6233
Alessia Potenza *Experimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0003-0298-7315
Zulma MagnaniExperimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Stefano BerettaSan Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCSS San Raffaele Scientific Institute, Milan, Italy.
Barbara CamisaExperimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Laura ConteExperimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Alessia AiraghiExperimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Neda MohammadiExperimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Laura PeraniPreclinical Imaging, Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0001-8616-3377
Claudio DoglioniPathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0002-4969-5216
Maurilio PonzoniPathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0002-0055-325X
Francesca SanvitoPathology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0002-4046-8420
Chiara BalestrieriExperimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0001-7362-3530
Lucia Sergi SergiExperimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Oronza A BotrugnoVita-Salute San Raffaele University, Milan, Italy.ORCID http://orcid.org/0000-0002-2568-9815
Giulio GiovannoniFunctional Genomics of Cancer Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Giovanni TononVita-Salute San Raffaele University, Milan, Italy.ORCID http://orcid.org/0000-0003-2973-5038
Danilo AbbatiExperimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0001-8517-7937
Chiara IozziExperimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Maximilian ReichertTranslational Pancreatic Cancer Research Center, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.ORCID http://orcid.org/0000-0002-8611-5639
Hana AlgulDepartment of Gastroenterology, Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany.
Arianna PocaterraLymphocyte activation Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Martina FiumaraSan Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCSS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0009-0007-5934-9273
Samuele FerrariSan Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCSS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0003-1122-1231
Alessia UgoliniExperimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Alice GromettoExperimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Giulia Di LulloExperimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Giovanni SitiaVita-Salute San Raffaele University, Milan, Italy.ORCID http://orcid.org/0000-0003-1024-9128
Giulio BelfioriPancreatic Surgery and Transplantation Unit, Pancreas Translational and Clinical Research Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Maria Pia ProttiTumor immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Renato OstuniSan Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCSS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0003-0460-3426
Anna MondinoLymphocyte activation Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Michele ReniVita-Salute San Raffaele University, Milan, Italy.
Stefano CrippaVita-Salute San Raffaele University, Milan, Italy.
Massimo FalconiVita-Salute San Raffaele University, Milan, Italy.ORCID http://orcid.org/0000-0001-9654-7243
Luigi NaldiniSan Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), IRCSS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0002-7835-527X
Eliana RuggieroExperimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0002-2954-8278
Chiara BoniniExperimental hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy. bonini.chiara@hsr.it.ORCID http://orcid.org/0000-0002-0772-1674

Funding

Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research) AIRC5x1000 22737Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research) AIRC-IG 18458Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research) ID 29914 - 2023
6 · The paper itself

Abstract

T-cell avidity is a major determinant of Adoptive T cell therapy (ACT) efficacy for cancer treatment. However, high-avidity tumor-specific T cells can rarely be isolated from cancer patients, highlighting the need for strategies to enhance the cytotoxic capacity of low-avidity cells. Here, we rescue the anti-tumor functions of low-avidity T cells against pancreatic ductal adenocarcinoma (PDAC) by knocking-out TIGIT, a key inhibitory molecule expressed on exhausted CD8

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsReceptors, Antigen, T-CellReceptors, ImmunologicAnimalsCD8-Positive T-LymphocytesCell Line, TumorHumansImmunotherapy, AdoptiveMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionT-Cell ExhaustionT-LymphocytesReceptors, Antigen, T-CellReceptors, ImmunologicTIGIT protein, human

Identifiers

PMID41507193
PMCPMC12808264

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.