Evidence map›Paper›PMID 41507321›Full record

ArticleScientific reports2026

Noninvasive biventricular pressure-strain-volume loop-derived myocardial work analysis in competitive athletes.

Andrea Ferencz, Ádám Szijártó, Tímea Katalin Turschl, Zsuzsanna Ladányi, Bálint Károly Lakatos, Márton Tokodi, Máté Tolvaj, Márk Zámodics, Máté Babity, Regina Benkő and 8 more

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Andrea FerenczHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary. ferencz.andrea12@gmail.com.
Ádám SzijártóHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.
Tímea Katalin TurschlHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.
Zsuzsanna LadányiHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.
Bálint Károly LakatosHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.
Márton TokodiHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.
Máté TolvajHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.
Márk ZámodicsHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.
Máté BabityHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.
Regina BenkőHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.
Orsolya KissHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.
Emese CsulakHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.
Nóra SydóHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.
Csongor MeskóHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.
Hajnalka VágóHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.
Béla MerkelyHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.
Attila Kovács *Heart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.
Alexandra Fábián *Heart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intense exercise imposes hemodynamic load on the heart, and while morphological remodeling is well-characterized, assessment of exercise-induced functional changes, like enhanced contractility, remains challenging. We aimed to introduce a novel 3D echocardiography (3DE)-derived method for noninvasive quantification of biventricular systolic function, less dependent on loading conditions in competitive athletes, and to explore the relationship with peak exercise capacity. We enrolled 260 athletes and 24 sedentary volunteers. All subjects underwent 3DE to measure left (LV) and right ventricular (RV) volumes and ejection fractions (EF). Biventricular global longitudinal strain (GLS) tracings and noninvasively estimated pressure curves were concatenated and further adjusted to instantaneous volumes to create pressure-strain-volume loops and derive volume-adjusted myocardial work (MW) indices (LV GWIV and RV GWIV). Athletes had lower biventricular EF and LV GLS, but significantly higher LV GWIV (10273 ± 2929 vs. 7387 ± 2050 mmHg%·mL, p < 0.001) and RV GWIV (3422 ± 1339 vs. 2436 ± 796 mmHg%·mL, p < 0.001) compared to controls. Among the functional echocardiographic parameters, RV GWIV showed the strongest correlation (r = 0.30, p < 0.001) and was an independent predictor of exercise capacity. Our novel metrics captured enhanced biventricular function in athletes at rest, and RV GWIV was independently associated with higher peak exercise capacity.

Indexed as

AthletesHeart VentriclesAdultEchocardiography, Three-DimensionalExerciseFemaleGlobal Longitudinal StrainHumansMaleMyocardial ContractionStroke VolumeVentricular Function, LeftVentricular Function, RightYoung Adult3D echocardiographyAthlete’s heartExercise capacityMyocardial workPressure-strain-volume loop analysisRight ventricle

Identifiers

PMID41507321
PMCPMC12873281

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.