Evidence map›Paper›PMID 41507348›Full record

ArticleEMBO reports2026

Mutual regulation of spermatogenesis-specific Argonaute proteins and Insulin/IGF-1 signaling in aging control.

Thomas Liontis, Valentina T Pannarale, Andrés R Mansisidor, Sasiru K Pathiranage, Jeeya Y Patel, Alla Grishok

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thomas LiontisDepartment of Biochemistry & Cell Biology, Chobanian & Avedisian School of Medicine, Boston University, 72 East Concord Street, Boston, MA, 02118, USA.ORCID 0000-0003-3376-1511
Valentina T PannaraleDepartment of Biochemistry & Cell Biology, Chobanian & Avedisian School of Medicine, Boston University, 72 East Concord Street, Boston, MA, 02118, USA.ORCID 0009-0004-5026-8926
Andrés R MansisidorDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA.ORCID 0000-0002-6607-4016
Sasiru K PathiranageDepartment of Biochemistry & Cell Biology, Chobanian & Avedisian School of Medicine, Boston University, 72 East Concord Street, Boston, MA, 02118, USA.ORCID 0009-0001-6938-7990
Jeeya Y PatelDepartment of Biochemistry & Cell Biology, Chobanian & Avedisian School of Medicine, Boston University, 72 East Concord Street, Boston, MA, 02118, USA.ORCID 0009-0003-7636-2438
Alla GrishokDepartment of Biochemistry & Cell Biology, Chobanian & Avedisian School of Medicine, Boston University, 72 East Concord Street, Boston, MA, 02118, USA. agrishok@bu.edu.ORCID 0000-0001-8922-7575

Funding

Hevolution Foundation (HF) HF-AGE-23-1268260-52HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM135199HHS | NIH | NIH Office of the Director (OD) OD010440
6 · The paper itself

Abstract

The potential role of small interfering RNAs (siRNAs) produced from double-stranded RNA in aging has not been fully addressed. The networks of genes regulated by siRNAs and their partner Argonaute proteins are best understood in C. elegans, a pioneering model of aging and small RNA studies. Here, we describe synergistic lifespan extension of insulin/IGF-1 signaling (IIS) mutant age-1(hx546) by rde-4 or alg-3; alg-4 deficiencies. By analyzing gene expression and siRNA populations in these IIS and RNAi mutants, we show here that redundant spermatogenesis-specific Argonautes ALG-3 and ALG-4 are capable of regulating IIS, potentially through direct control of the Major Sperm Protein (MSP) genes in the germline. MSPs and MSP domains of some mammalian proteins are secreted and directly inhibit the Eph receptor (EphR). In turn, EphR interacts with and destabilizes PTEN, a major negative regulator of IIS. We show that enhanced MSP expression correlates with EphR mislocalization and elevated PTEN levels in oocytes of alg-3/4(-) worms. At the same time, ALG-3/4 expression is regulated by IIS. Thus, we propose mutual regulation of IIS and ALG-3/4 through secreted ligands.

Indexed as

AgingArgonaute ProteinsCaenorhabditis elegansCaenorhabditis elegans ProteinsInsulinInsulin-Like Growth Factor ISignal TransductionSpermatogenesisAnimalsGene Expression RegulationMaleMutationPTEN PhosphohydrolaseReceptors, Eph FamilyRNA InterferenceRNA, Small InterferingArgonaute ProteinsCaenorhabditis elegans ProteinsInsulinInsulin-Like Growth Factor IPTEN PhosphohydrolaseReceptors, Eph FamilyRNA, Small InterferingSperm ProteinsArgonauteEphRInsulin/IGF-1 SignalingMSPsiRNA

Identifiers

PMID41507348
PMCPMC13021995

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.