ArticleThe Journal of antibiotics2026
1-Hydroxy-1-Norresistoflavins B and C, resistomycin-type polyketides from the Marine-Derived Streptomyces althioticus 2304JJ-041.
Article in The Journal of antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
Abstract
Two new resistomycin-type pentacyclic polyketide derivatives, designated 1-hydroxy-1-norresistoflavins B (1) and C (2), together with 1R-hydroxy-1-norresistomycin (3) and (6 R)-6,11-Dihydro-7-hydroxy-6-(hydroxymethyl)-8-methoxy-3,9-dimethyl-4H-pyrazino[1,2-b]isoquinolin-4-one (4), were isolated from the marine-derived actinomycete Streptomyces althioticus. Their structures were elucidated by comprehensive spectroscopic analyses, including 1D and 2D NMR and HR-ESIMS data, and the absolute configurations were determined by comparison with experimental and calculated electronic circular dichroism (ECD) spectra. In addition, the absolute configuration of 3 was experimentally determined for the first time based on its ECD data. All isolated compounds were evaluated for cytotoxicity against a panel of six solid cancer cell lines and seven blood cancer cell lines. Compound 3 exhibited significant cytotoxicity against several blood cancer cell lines, with GI
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Registered trials
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