SynthesisOral diseases2026
MRONJ Risk Related to Dental Implants in Osteoporosis Treated With Denosumab: A Systematic Review.
Synthesis in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Risk of medication-related osteonecrosis of the jaws (MRONJ) in osteoporotic patients treated with antiresorptive drug therapy and dental implants.Evidence-based dentistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this systematic review was to assess the impact of dental implants in osteoporotic patients undergoing treatment with denosumab on MRONJ development, considering both implant surgery-triggered osteonecrosis (ISTO) and implant presence-triggered osteonecrosis (IPTO).
methodsAn electronic literature search was conducted applying the clinical PICO question, "What is the effect of dental implants on the risk of developing MRONJ in osteoporotic patients undergoing treatment with denosumab?" The full texts of 239 retrieved articles were screened, and 10 studies were included in the quality assessment and data extraction process.
results10 articles were selected for data extraction: 6 case series, 2 cohort studies, 1 case control study, and 1 randomized controlled trial. The main findings reported in these studies were evaluated, including factors such as the timing of implant placement, the influence of peri-implantitis and comorbidities, antiresorptive therapy, and the cases of MRONJ.
conclusionsThe current literature shows high heterogeneity, small sample sizes, and a lack of standardization, making it difficult to draw definitive conclusions. However, despite MRONJ being relatively rare, important factors were identified that could influence outcomes, such as transitioning from bisphosphonates to denosumab therapy, timing of implant placement, and the presence of peri-implantitis.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.