SynthesisBMC public health2026
Association of frailty and mortality risk in community-dwelling older adults: a systematic review and meta-analysis of 59 international prospective cohort studies.
Synthesis in BMC public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hypertension and frailty in older adults: a bibliometric analysis and knowledge mapping based on Web of Science, Scopus, and PubMed (1973-2025).Frontiers in medicine · 2026Pooled it
- Sugar rationing in the first 1000 days of life and risk of frailty: evidence from a natural experiment.The journal of nutrition, health & aging · 2026Article
- Association Between Health Literacy and One-Year Incidence of Pre-Frailty Among Older Adults Undergoing Frailty Health Checkups.Geriatrics (Basel, Switzerland) · 2026Article
- Early nurse-assessed intrinsic capacity stratifies rehospitalization risk after percutaneous coronary intervention in coronary artery disease patients.Frontiers in cardiovascular medicine · 2026Article
- Ischemic Heart Disease and the Epidemiologic Transition: Progress without Reduction in Global Burden.Discoveries (Craiova, Romania)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundThe global aging population presents significant health challenges. This study aimed to examine the association between frailty and mortality among community-dwelling older adults.
methodsWe searched five databases up to April 29, 2025, for prospective cohort studies evaluating frailty as a predictor of mortality. Study quality and risk of bias were assessed using the ROBINS-E tool. A random-effects meta-analysis was conducted to estimate pooled mortality risks.
resultsA total of 59 studies were included in the systematic review, of which 53 were eligible for meta-analysis, comprising 185,355 participants and over 28,616 deaths. Follow-up periods ranged from 1 to 15 years. Compared to robust individuals, non-robust older adults had a significantly higher risk of all-cause mortality (hazard ratio [HR] = 1.83, 95% confidence interval [CI]: 1.70-1.97). This association was consistent across frailty domains: including physical frailty (HR = 1.74, 95%CI: 1.53-1.99), multidimensional frailty (HR = 2.25, 95%CI: 1.97-2.57), and phenotype-based models accessed frailty (HR = 1.71, 95%CI: 1.48-1.97). Subgroup analyses based on phenotype-based models showed that frail older adults had a higher risk of all-cause mortality (HR = 2.18, 95%CI: 1.72-2.75) than those who were prefrail (HR = 1.51, 95%CI: 1.37-1.67), with a significant difference across frailty levels (Q = 7.88, p < .01). Regarding cause-specific mortality, the risk of death from non-lifestyle-related diseases (e.g., dementia, cancer) (HR = 1.97, 95%CI: 1.36-2.84) was slightly higher than that from lifestyle-related diseases (e.g., cardiovascular and respiratory diseases) (HR = 1.94, 95%CI: 1.52-2.46), though the difference was not statistically significant (Q = 0.008, p > .05).
conclusionsThese findings highlight the need for comprehensive assessment and management of frailty in community-dwelling older adults. Future research and health policy should prioritize targeted strategies according to frailty severity to reduce mortality risk and improve health outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.