Evidence map›Paper›PMID 41507973›Full record

ArticleCell communication and signaling : CCS2026

Fibroblast-derived POSTN promotes colorectal cancer progression under high-fat diet by reprogramming fatty acid metabolism in tumor cell.

Biao Li, Shasha Hou, Tian Tian, Shuai Yuan, Anrui Li, Yao Feng, Zhuoxi Liu, Jing Mi, Zhengyi Cheng, Shengnan Lv and 6 more

Abstract read
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In one paragraph

Article in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Biao Li *College of Life Sciences, Mudanjiang Medical University, No.3 Tongxiang Road, Mudanjiang, 157011, China.
Shasha Hou *Department of Life Science and Engineering, Jining University, Jining, China.
Tian Tian *College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing, China.
Shuai YuanSchool of Basic Medicine, Qiqihar Medical University, Qiqihar, China.
Anrui LiDepartment of urology, Harbin Medical University Cancer Hospital, Harbin, China.
Yao FengClinical Medical School, Jiamusi University, Jiamusi, China.
Zhuoxi LiuThe Second Affiliated Hospital of Mudanjiang Medical University, Mudanjiang, China.
Jing MiCollege of Life Sciences, Mudanjiang Medical University, No.3 Tongxiang Road, Mudanjiang, 157011, China.
Zhengyi ChengDepartment of Pathology, The Affiliated Hospital of Northwest University, Xi'an No.3 Hospital, Xi'an, China.
Shengnan LvCollege of Life Sciences, Mudanjiang Medical University, No.3 Tongxiang Road, Mudanjiang, 157011, China.
Jiajun YangCollege of Life Sciences, Mudanjiang Medical University, No.3 Tongxiang Road, Mudanjiang, 157011, China.
Yiming LuSchool of Basic Medicine, Mudanjiang Medical University, Mudanjiang, China.
Xinlai QiSchool of Basic Medicine, Mudanjiang Medical University, Mudanjiang, China.
Shiqi SongSchool of Basic Medicine, Mudanjiang Medical University, Mudanjiang, China.
Zijuan ZhaSchool of Basic Medicine, Mudanjiang Medical University, Mudanjiang, China.
Qi YuanCollege of Life Sciences, Mudanjiang Medical University, No.3 Tongxiang Road, Mudanjiang, 157011, China. yuanqi@mdjmu.edu.cn.

Funding

Basic Research Fund of Universities in Heilongjiang Province 2023-KYYWFMY-0002Heilongjiang Provincial Natural Science Foundation of China YQ2023H018National Natural Science Foundation of China 82303285Natural Science Foundation of Beijing 5222019
6 · The paper itself

Abstract

Abnormal expression of POSTN is closely related to the development of cancer, especially in colorectal cancer (CRC). However, the effects and mechanisms of POSTN on CRC progression under high-fat diet (HFD) have not been thoroughly studied. The effect of POSTN on HFD-induced CRC was evaluated in vitro and in vivo, and the dynamic changes of different lipid metabolizing enzyme expression were analyzed. Molecular and biological experiments have revealed the underlying mechanisms of POSTN regulating the production of fat accumulation and fatty acid oxidation (FAO) dysregulation. POSTN expression was significantly increased in CRC patients, and was correlated with clinical poor prognosis, mainly derived from myCAF. Deletion of fibroblast-derived POSTN inhibits CRC progression under HFD. Mechanistically, fibroblast-derived POSTN promotes the expression of SREBP1 in tumor cells by regulating the AKT signaling pathway, thereby promoting fatty acid (FA) synthesis. At the same time, fibroblast-derived POSTN inhibits the activity of FAO-related enzyme CPT1A in tumor cells through the ERK signaling pathway, thus inhibiting the FAO process. In addition, we found that CD51 (POSTN receptor) inhibitor Cilengitide effectively inhibits abnormal proliferation of CRC cells, thereby inhibiting tumor development in the HFD environment.

Indexed as

Colorectal NeoplasmsDiet, High-FatDisease ProgressionFatty AcidsFibroblastsPeriostinAnimalsCarnitine O-PalmitoyltransferaseCell Adhesion MoleculesCell Line, TumorCell ProliferationHumansMaleMetabolic ReprogrammingMiceProto-Oncogene Proteins c-aktCarnitine O-PalmitoyltransferaseCell Adhesion MoleculesFatty AcidsPeriostinPOSTN protein, humanProto-Oncogene Proteins c-aktSterol Regulatory Element Binding Protein 1Colorectal cancerCPT1AFatty acid metabolismPOSTNSREBP1

Identifiers

PMID41507973
PMCPMC12870062

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.