ArticleChinese medicine2026
Acupuncture ameliorates diet-induced obesity via the vagal-GLP-1-ARC circuit: neural mechanism of anorexigenic action.
Article in Chinese medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Acupuncture modulates migraine-related neural and neuroendocrine regulatory pathways.The journal of headache and pain · 2026Review
- Endogenous neuroprotection in vascular cognitive impairment and dementia.EBioMedicine · 2026Review
- Transcutaneous auricular vagus nerve stimulation to alleviate metformin-associated gastrointestinal adverse events and optimize glycaemic control: a randomized, sham-controlled pilot trial protocol.Frontiers in neuroscience · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundElectroacupuncture (EA) has demonstrated efficacy in ameliorating obesity through its marked appetite-suppressing effects. This study aims to elucidate the peripheral-central communication mechanism underlying EA's appetite inhibition mediated by the "vagal afferent fiber-nucleus tractus solitarius (NTS)-hypothalamic arcuate nucleus (ARC)" neural circuit.
methodsHigh-fat diet-induced obese rats received EA or transcutaneous auricular vagus nerve stimulation (taVNS) for 8 weeks. Furthermore, we employed chemogenetic approaches to activate NTS glucagon-like peptide-1 (GLP-1) neurons (NTS
resultsWe observed reduced expression of GLP-1 in the NTS of obese rats. Chemogenetic activation of NTS
conclusionThe therapeutic benefits of EA in appetite suppression and obesity mitigation are mediated by selective regulation of the "vagal-GLP-1-ARC" neural circuit.
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