ArticleArchives of public health = Archives belges de sante publique2026
Bodyweight increase since early adulthood as a risk factor for mobility decline: a 7-year longitudinal study of 10,316 Japanese adults aged ≥ 40 years.
Article in Archives of public health = Archives belges de sante publique, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundBodyweight increase since early adulthood is a risk factor for lifestyle-related diseases and may be a predictor of mobility decline. Locomotive syndrome (LS) is a condition characterized by reduced mobility due to musculoskeletal impairments, and its severity reflects the degree of mobility decline. This study aimed to investigate the association between a bodyweight increase of ≥ 10 kg since age 20 and the progression of LS severity.
methodsThis was a 7-year longitudinal observational study including 10,316 Japanese adults aged ≥ 40 years who underwent health checkups in 2016 and 2023. Total bodyweight increase from age 20 to baseline was self-reported. Based on established cut-off values, LS severity was assessed using the 25-question Geriatric Locomotive Function Scale (GLFS-25), the two-step test, the stand-up test, and total assessment according to predefined criteria. LS progression was defined as a worsening by at least one LS severity category from 2016 to 2023; all others, including those with persistently non-LS status, were classified as non-progression. A multivariate logistic regression analysis was performed to examine associations, adjusting for potential confounders. Considering age-related weight changes in older adults, a sensitivity analysis was performed, restricted to participants aged 40–65 years (n = 9994).
resultsThe mean age of the participants was 50.0 years (range, 40–84 years), and 4044 (39.2%) were female. Of the 10,316 participants, 3530 (34.2%) showed an increase in body weight from age 20 to baseline of ≥ 10 kg. A bodyweight increase of ≥ 10 kg was significantly associated with the progression of LS severity assessed by the GLFS-25 (odds ratio [OR]: 1.38, 95% confidence interval [CI]: 1.11–1.71), the stand-up test (OR: 1.20, 95% CI: 1.00–1.45), and the total assessment (OR: 1.23, 95% CI: 1.05–1.44), but not by the two-step test (OR: 0.99, 95% CI: 0.70–1.42). The sensitivity analysis results were generally consistent, indicating the robustness of our findings.
conclusionsA bodyweight increase of ≥ 10 kg since early adulthood was associated with the progression of LS severity assessed by the GLFS-25, the stand-up test, and the total assessment. Therefore, midlife weight management is crucial to preventing mobility decline at older age.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.