Evidence map›Paper›PMID 41508796›Full record

SynthesisJournal of surgical oncology2026

Long Term Metabolic Outcomes Following Pancreatectomy and Autologous Islet Transplantation: Systematic Review and Meta-Analysis.

Daniel L Hughes, Caterina Di Bella, Benedetta Quaratino, Pietro Rigo, Giulia Cirillo, Gioia Sgrinzato, Umberto Cillo, Lucrezia Furian, Giovanni Marchegiani

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniel L HughesDepartment of Hepato-Pancreato-Biliary Surgery, Oxford University Hospitals NHS Foundation trust, Oxford.
Caterina Di BellaDepartment of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Italy.
Benedetta QuaratinoDepartment of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Italy.
Pietro RigoDepartment of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Italy.ORCID https://orcid.org/0009-0007-1590-0078
Giulia CirilloDepartment of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Italy.
Gioia SgrinzatoDepartment of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Italy.
Umberto CilloDepartment of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Italy.
Lucrezia FurianDepartment of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Italy.ORCID https://orcid.org/0000-0002-2264-7986
Giovanni MarchegianiDepartment of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Italy.ORCID https://orcid.org/0000-0002-6824-4533

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This systematic review and meta-analysis assessed long-term outcomes following total pancreatectomy with islet autotransplantation (TPIAT). Seventeen studies including 1332 patients were analyzed. The pooled insulin independence rate was 34%, with higher rates for non-chronic pancreatitis indications (68%) versus chronic pancreatitis (33%). TPIAT is effective in preserving endocrine function. Further studies are needed to validate outcomes across extended indications and to standardize reporting, incorporating metabolic markers and patient-reported quality-of-life endpoints over long-term follow-up.

Indexed as

Islets of Langerhans TransplantationPancreatectomyHumansPancreatitis, ChronicQuality of LifeTransplantation, AutologousTreatment OutcomeAutologous Islet TransplantationMetabolic outcomesTotal PancreatectomyTPIATtype 3c diabetes

Identifiers

PMID41508796
PMCPMC12989187

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.