Evidence map›Paper›PMID 41508868›Full record

ArticleTissue barriers2026

Permeation of small extracellular vesicles across a human blood-brain barrier transwell model remains below particle detection limits, even under oxygen/glucose deprived conditions.

Adrián Klepe, Sonja Damberger, Ana Špilak, Andreas Brachner, Winfried Neuhaus

Abstract read
In one paragraph

Article in Tissue barriers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Adrián KlepeCompetence Unit Molecular Diagnostics, Center for Health and Bioresources, AIT - Austrian Institute of Technology Gmbh Vienna, Austria.ORCID 0000-0002-1315-6376
Sonja DambergerCompetence Unit Molecular Diagnostics, Center for Health and Bioresources, AIT - Austrian Institute of Technology Gmbh Vienna, Austria.ORCID 0009-0001-6841-6833
Ana ŠpilakCompetence Unit Molecular Diagnostics, Center for Health and Bioresources, AIT - Austrian Institute of Technology Gmbh Vienna, Austria.ORCID 0000-0001-7800-2469
Andreas BrachnerCompetence Unit Molecular Diagnostics, Center for Health and Bioresources, AIT - Austrian Institute of Technology Gmbh Vienna, Austria.ORCID 0000-0002-9465-8561
Winfried NeuhausCompetence Unit Molecular Diagnostics, Center for Health and Bioresources, AIT - Austrian Institute of Technology Gmbh Vienna, Austria.ORCID 0000-0002-6552-7183

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke disrupts blood-brain barrier (BBB) integrity and alters small extracellular vesicle (sEV) signaling, yet the mechanisms underlying sEV transport across compromised barriers remain poorly understood. This study investigated BBB-sEV interactions under normal and stroke-mimicking oxygen/glucose deprivation (OGD) conditions using an

Indexed as

Blood-Brain BarrierExtracellular VesiclesGlucoseOxygenCoculture TechniquesEndothelial CellsHumansGlucoseOxygenBlood-brain barrierin vitro modelpermeationsmall extracellular vesiclesstrokeuptake

Identifiers

PMID41508868
PMCPMC13540092

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.