Evidence map›Paper›PMID 41509167›Full record

ArticleBioMed research international2026

Condylar Bone Quality in Growing Children Is Associated With Genetic Polymorphisms in Genes Involved in Calcium and Phosphate Maintenance.

Erika Calvano Küchler, Caio Luiz Bitencourt Reis, Gabriela Fonseca-Souza, Daniel Hemming, Flares Baratto-Filho, Cristiano Miranda de Araujo, Svenja Beisel-Memmert, Juliana Feltrin-Souza, Michelle Nascimento Meger, Bianca Lopes Cavalcante-Leão

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In one paragraph

Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Erika Calvano KüchlerDepartment of Orthodontics, Medical Faculty, University Hospital Bonn, Bonn, Germany, uni-bonn.de.ORCID https://orcid.org/0000-0001-5351-2526
Caio Luiz Bitencourt ReisSchool of Dentistry, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil, unifal-mg.edu.br.ORCID https://orcid.org/0000-0003-0606-1632
Gabriela Fonseca-SouzaDepartment of Stomatology, Federal Paraná University, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0002-8040-8553
Daniel HemmingSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0009-0005-3141-8906
Flares Baratto-FilhoSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0002-5649-7234
Cristiano Miranda de AraujoSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0003-1325-4248
Svenja Beisel-MemmertDepartment of Orthodontics, Medical Faculty, University Hospital Bonn, Bonn, Germany, uni-bonn.de.ORCID https://orcid.org/0000-0002-8153-6610
Juliana Feltrin-SouzaDepartment of Stomatology, Federal Paraná University, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0001-9969-3721
Michelle Nascimento MegerSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0002-1776-2373
Bianca Lopes Cavalcante-LeãoSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0002-6170-1914

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single nucleotide polymorphisms (SNPs) play a crucial role in regulating vitamin D, parathyroid hormone (PTH), and calcitonin concentrations, which are involved in bone health. Some reports suggested that fractal analysis is useful in the morphometric analysis of the mandible trabecular bone in panoramic radiographs. Therefore, we investigated if SNPs in genes that influence vitamin D, calcitonin, and PTH levels are involved in condylar bone quality during the active growing phase of the mandible. Fractal dimension was obtained from the condyle region of interest (ROI) using panoramic radiographs and used to measure the complexity and the microarchitecture of the bone. Fractal dimension using the box-counting algorithm was then calculated. In order to avoid information bias, a script to automate the commands in the software ImageJ was generated to ensure consistency and minimize the potential for human error during the data analysis process. SNPs in vitamin D receptor (

Indexed as

CalciumMandibular CondylePhosphatesPolymorphism, Single Nucleotide25-Hydroxyvitamin D3 1-alpha-HydroxylaseBone DensityCalcitoninChildFemaleHumansMaleParathyroid HormoneReceptors, CalcitoninReceptors, CalcitriolVitamin D3 24-HydroxylaseVitamin D-Binding Protein25-Hydroxyvitamin D3 1-alpha-HydroxylaseCalcitoninCalciumCYP24A1 protein, humanCYP27B1 protein, humanParathyroid HormonePhosphatesPTH protein, humanReceptors, CalcitoninReceptors, CalcitriolVDR protein, humanVitamin D3 24-HydroxylaseVitamin D-Binding Proteinfractal dimension analysismandibular condylepanoramic radiographyvitamin D receptor

Identifiers

PMID41509167
PMCPMC12776005

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.