Evidence map›Paper›PMID 41509243›Full record

ArticlebioRxiv : the preprint server for biology2025

Endothelial Arf6 sustains capillary electrical signaling and cerebral blood flow through PIP

Maria F Noterman-Soulinthavong, María Sancho, Saúl Huerta de la Cruz, Michael Yarboro, Maurizio Mandala, Masayo Koide, Nathalie Beaufort, Katalin Todorov-Völgyi, Emma Moreland, David Hill-Eubanks and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Maria F Noterman-SoulinthavongDepartment of Pharmacology, University of Vermont, Burlington, VT, United States.ORCID 0000-0001-8524-2604
María SanchoDepartment of Pharmacology, University of Vermont, Burlington, VT, United States.ORCID 0000-0003-4750-1040
Saúl Huerta de la CruzDepartment of Pharmacology, University of Vermont, Burlington, VT, United States.ORCID 0000-0002-5968-9506
Michael YarboroDepartment of Pharmacology, University of Vermont, Burlington, VT, United States.ORCID 0000-0003-1915-1979
Maurizio MandalaDepartment of Biology, Ecology and Earth Sciences, University of Calabria, Italy.ORCID 0000-0003-3736-0205
Masayo KoideDepartment of Pharmacology, University of Vermont, Burlington, VT, United States.ORCID 0000-0002-1381-7074
Nathalie BeaufortInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0000-0002-7088-4206
Katalin Todorov-VölgyiInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID 0009-0007-8073-9524
Emma MorelandDepartment of Pharmacology, University of Vermont, Burlington, VT, United States.
David Hill-EubanksDepartment of Pharmacology, University of Vermont, Burlington, VT, United States.
Martin DichgansInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
Mark T NelsonDepartment of Pharmacology, University of Vermont, Burlington, VT, United States.ORCID 0000-0002-6608-8784

Funding

Vermont Center for Cardiovascular and Brain HealthP20GM135007 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Diego Adrianzen Herrera · 2020 to 2026
$17.4M
Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and DiseaseR35HL140027 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2025
$6.3M
Cerebral Microvascular Signaling and Neurovascular Coupling: An Integrated Approach to Investigate VCIDR01NS119971 · NINDS · FLORIDA INTERNATIONAL UNIVERSITY · PI TSOUKIAS, NIKOLAOS MICHAEL · 2021 to 2025
$2.6M
Ion Channel Dysfunction in Small Vessel Disease of the BrainR01NS110656 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2023
$2.6M
Lesions and loss of smooth muscle cells in brain underlies small vessel diseaseRF1NS128963 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JOUTEL, ANNE, NELSON, MARK T · 2022 to 2023
$2.2M
Lesions and Loss of Smooth Muscle Cells in Brain Underlies Small Vessel DiseaseR01NS128963 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MARK T NELSON · 2025 to 2026
$1.3M
Aldosterone-Vascular Signaling on Cerebral Small Vessel FunctionR01NS140868 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Masayo Koide · 2025 to 2026
$1.2M
NHLBI NIH HHS R35 HL140027NIGMS NIH HHS P20 GM135007NINDS NIH HHS R01 NS110656NINDS NIH HHS R01 NS119971NINDS NIH HHS R01 NS128963NINDS NIH HHS R01 NS140868NINDS NIH HHS RF1 NS128963
6 · The paper itself

Abstract

Brain capillaries sense neural activity and direct blood flow to active regions-a process termed neurovascular coupling that underlies activity-dependent increases in local perfusion (functional hyperemia). A key contributor to functional hyperemic responses is the capillary endothelial cell (cEC) inward rectifier K

Indexed as

ADP-ribosylation factor 6Biological SciencesCerebral blood flowendothelial cellsKir2.1 channelsphosphatidylinositol-4,5-bisphosphatePhysiology

Identifiers

PMID41509243
PMCPMC12776107

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.