ArticlebioRxiv : the preprint server for biology2025
Intrinsic and non-cell autonomous roles for a neurodevelopmental syndrome-linked transcription factor.
Jayson J Smith, Seth R Taylor, Honorine Destain, Grace Kim, David H Hall, John G White, David M Miller, Paschalis Kratsios
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
Jayson J SmithDepartment of Neurobiology, University of Chicago, Chicago, IL, 60637, USA.
Seth R TaylorDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, 37240, USA.ORCID 0000-0002-2227-1050 Honorine DestainDepartment of Neurobiology, University of Chicago, Chicago, IL, 60637, USA.
Grace KimDepartment of Neuroscience, Albert Einstein College of Medicine, NY, 10461, USA.
David H HallDepartment of Neuroscience, Albert Einstein College of Medicine, NY, 10461, USA.
John G WhiteMRC Laboratory of Molecular Biology, Cambridge, UK.
David M MillerDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, 37240, USA.
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MDiscovery and analysis of the C. elegans neuronal gene expression network (CENGEN)R01NS100547 · NINDS · YALE UNIVERSITY · PI MARC HAMMARLUND, Oliver Hobert · 2017 to 2026
$11.2MVANTAGE:Consolidation to create the Vanderbilt Technologies for Advanced GenomicsG20RR030956 · NCRR · VANDERBILT UNIVERSITY · PI PIETENPOL, JENNIFER A · 2010 to 2010
$8.7MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5MMolecular Genetics of Synaptic PlasticityR01NS106951 · NINDS · VANDERBILT UNIVERSITY · PI BIANCHI, LAURA, MILLER, DAVID M · 2018 to 2022
$2.2MHox-dependent mechanisms for establishment and maintenance of motor neuron terminal identityR01NS116365 · NINDS · UNIVERSITY OF CHICAGO · PI KRATSIOS, PASCHALIS · 2020 to 2024
$2.0MMolecular mechanisms for neuron-specific assembly of electrical synapsesR01NS113559 · NINDS · VANDERBILT UNIVERSITY · PI MILLER, DAVID M · 2020 to 2024
$1.8MMolecular mechanisms of motor neuron terminal identityR01NS118078 · NINDS · UNIVERSITY OF CHICAGO · PI KRATSIOS, PASCHALIS · 2020 to 2024
$1.8MNCI NIH HHS P30 CA068485NCRR NIH HHS G20 RR030956NCRR NIH HHS UL1 RR024975NEI NIH HHS P30 EY008126NIDDK NIH HHS P30 DK058404NIDDK NIH HHS U24 DK059637NIH HHS P40 OD010440NINDS NIH HHS K99 NS140549NINDS NIH HHS R01 NS100547NINDS NIH HHS R01 NS106951NINDS NIH HHS R01 NS113559NINDS NIH HHS R01 NS116365NINDS NIH HHS R01 NS118078NINDS NIH HHS R21 NS108505
6 · The paper itselfAbstract
Transcription factors (TFs) are essential for neuronal identity, yet their potential non-cell-autonomous functions remain largely unexplored. Here, we uncover both cell- and non-cell-autonomous roles for the conserved terminal selector UNC-3 in
Identifiers
PMID41509263
PMCPMC12776094
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