Evidence map›Paper›PMID 41509270›Full record

ArticlebioRxiv : the preprint server for biology2025

Copy Number Variation-Based Molecular Sexing of

Arvind Sharma, Benjamin Faustino, Isaac Hinne, Jakub Wudarski, Saransh Beniwal, Nurul Hamidi, Kyla Ercit, Sanjay Basu, Lisulo Malimba, Mattia Poletto and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Arvind SharmaDepartment of Biochemistry, Molecular Biology, and Biotechnology, University of Nevada, Reno, Reno, NV, USA.
Benjamin FaustinoDepartment of Biochemistry, Molecular Biology, and Biotechnology, University of Nevada, Reno, Reno, NV, USA.
Isaac HinneDepartment of Biochemistry, Molecular Biology, and Biotechnology, University of Nevada, Reno, Reno, NV, USA.
Jakub WudarskiDepartment of Biochemistry, Molecular Biology, and Biotechnology, University of Nevada, Reno, Reno, NV, USA.
Saransh BeniwalDepartment of Biochemistry, Molecular Biology, and Biotechnology, University of Nevada, Reno, Reno, NV, USA.
Nurul HamidiOxitec Ltd, 71 Innovation Drive, Milton Park, Abingdon, OX14 4RQ, UK.
Kyla ErcitOxitec Ltd, 71 Innovation Drive, Milton Park, Abingdon, OX14 4RQ, UK.
Sanjay BasuOxitec Ltd, 71 Innovation Drive, Milton Park, Abingdon, OX14 4RQ, UK.
Lisulo MalimbaDivision of Immunology, The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, United Kingdom.
Mattia PolettoOxitec Ltd, 71 Innovation Drive, Milton Park, Abingdon, OX14 4RQ, UK.
Kelly J MatzenOxitec Ltd, 71 Innovation Drive, Milton Park, Abingdon, OX14 4RQ, UK.ORCID 0000-0002-1167-7397
Monika Gulia-NussDepartment of Biochemistry, Molecular Biology, and Biotechnology, University of Nevada, Reno, Reno, NV, USA.ORCID 0000-0001-7095-1037

Funding

Germline Transformation of TicksR01AI172943 · NIAID · UNIVERSITY OF NEVADA RENO · PI Monika Gulia-Nuss · 2023 to 2026
$2.7M
Identification of stage-and tissue-specific endogenous tick promotersR21AI176352 · NIAID · UNIVERSITY OF NEVADA RENO · PI GULIA-NUSS, MONIKA · 2023 to 2024
$439k
Development of transgenic protocols for the Lyme disease vector, Ixodes scapularis, for tick and tick-borne disease controlR21AI128393 · NIAID · UNIVERSITY OF NEVADA RENO · PI GULIA-NUSS, MONIKA · 2018 to 2019
$408k
New molecular targets for pest management in the cuticle of the Lyme disease vector, Ixodes scapularisR21AI139778 · NIAID · UNIVERSITY OF NEVADA RENO · PI BLOMQUIST, GARY, GULIA-NUSS, MONIKA · 2019 to 2020
$403k
Gates Foundation INV-025721NIAID NIH HHS R01 AI172943NIAID NIH HHS R21 AI128393NIAID NIH HHS R21 AI139778NIAID NIH HHS R21 AI176352
6 · The paper itself

Abstract

Accurate sex identification of immature ticks is essential for understanding sex-specific ecological dynamics, pathogen transmission, and reproductive biology. However, tick larvae and nymphs lack morphological sexual dimorphisms, limiting the studies. Here, we report the development and validation of copy number variation (CNV)-based molecular sexing approach for two important hard tick species,

Identifiers

PMID41509270
PMCPMC12776140

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.