Evidence map›Paper›PMID 41509346›Full record

ArticlebioRxiv : the preprint server for biology2026

Aging, matrix metalloproteinase imaging, and survival prospects in aortic aneurysm.

Mean Ghim, Onur Varli, Azmi A Ahmad, Afarin Neishabouri, Gunjan Kukreja, Zhengxing Zhang, Saalar Zarnegar, Nicholas Gangemi, Jakub Toczek, Jiasheng Zhang and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mean GhimYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Onur VarliYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Azmi A AhmadYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Afarin NeishabouriYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Gunjan KukrejaYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Zhengxing ZhangYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Saalar ZarnegarYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Nicholas GangemiYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Jakub ToczekYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Jiasheng ZhangYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Chi LiuDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Yongjian LiuDepartment of Radiology, Washington University, St. Louis, MO, USA.ORCID 0000-0002-1118-1535
Robert J GroplerDepartment of Radiology, Washington University, St. Louis, MO, USA.
Mehran M SadeghiYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-5074-3510

Funding

Molecular Imaging of Collagen Turnover in CardiomyopathyR01HL161746 · YALE UNIVERSITY · 2025 to 2025
$796k
Training in Multi-Modality Molecular and Transitional Cardiovascular ImagingT32HL098069 · YALE UNIVERSITY · 2025 to 2025
$438k
BLRD VA I01 BX006089BLRD VA I01 BX006098NHLBI NIH HHS R01 HL161746NHLBI NIH HHS T32 HL098069NIA NIH HHS R01 AG065917
6 · The paper itself

Abstract

Age is a risk factor for aortic aneurysm (AA), and different segments of the aorta exhibit varying susceptibilities to aneurysm. The specific factors that contribute to the higher incidence of AA and its complications with aging remain unclear. Matrix metalloproteinases (MMPs) are elevated in AA. However, the connection between aging, aortic MMP activity, and the increased prevalence of AA and its complications has not been systematically evaluated. This study leveraged MMP-targeted molecular imaging to investigate how aging affects aortic MMP expression and activity, as well as aneurysm development and survival. Methods: AA development and animal survival were monitored for 28 days after Angiotensin (Ang)-II infusion in 8-10-week-old (young) and >51-week-old (old) Results: Old animals' survival to 28 days was significantly lower than that of young Ang-II-infused Conclusion: Aging is associated with increased MMP activity along the aorta and worse AA survival. MMP-targeted molecular imaging can inform the aneurysm survival prospects. Selective MMP inhibitors and tracers may help prevent and track aneurysm growth, dissection, and rupture.

Indexed as

AgingAortic aneurysmsMatrix metalloproteinasesMolecular ImagingPET/CT

Identifiers

PMID41509346
PMCPMC12776370

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.