Evidence map›Paper›PMID 41509392›Full record

ArticlebioRxiv : the preprint server for biology2025

IKAROS Gene Regulatory Network Reveal ERG as a Vulnerability in B-cell Acute Lymphoblastic Leukemia.

Hana Paculova, Alyssa Richman, Joseph Boyd, Joshua Carlos Bernil, Princess Rodriguez, Etapong Ayongaba, Prachi Ghule, Elsa Drivet, Amrita Palaria, Mariam Dajani and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hana PaculovaUniversity of Vermont, Department of Biomedical and Health Sciences, Burlington, VT.ORCID 0000-0002-4719-723X
Alyssa RichmanUniversity of Vermont, Department of Biomedical and Health Sciences, Burlington, VT.ORCID 0009-0001-2148-2892
Joseph BoydUniversity of Vermont, Department of Biomedical and Health Sciences, Burlington, VT.ORCID 0000-0002-8969-9676
Joshua Carlos BernilUniversity of California San Francisco, Department of Laboratory Medicine, San Francisco, CA.ORCID 0009-0008-9261-8911
Princess RodriguezUniversity Vermont, Department of Molecular Genetics and Microbiology, Burlington, VT.ORCID 0009-0003-0790-9890
Etapong AyongabaUniversity of California San Francisco, Department of Laboratory Medicine, San Francisco, CA.
Prachi GhuleUniversity Vermont, Department of Biochemistry, Burlington, VT.ORCID 0000-0002-8640-5070
Elsa DrivetUniversity of Oslo, Institute of Clinical Medicine, Department of Immunology and KG Jebsen Center for B-cell Malignancies, Oslo, Norway.ORCID 0009-0006-3481-4071
Amrita PalariaUniversity of California San Francisco, Department of Laboratory Medicine, San Francisco, CA.ORCID 0000-0003-2107-401X
Mariam DajaniUniversity of California San Francisco, Department of Laboratory Medicine, San Francisco, CA.
Els VerhoeyenUniversité Côte d'Azur, INSERM, C3M, 06204 Nice, France.
Anthony SaviolaUniversity of Colorado Denver Anschutz Medical Campus, Aurora, CO.ORCID 0000-0001-6890-512X
Gary S SteinUniversity Vermont, Department of Biochemistry, Burlington, VT.
Hilde SchjervenUniversity of California San Francisco, Department of Laboratory Medicine, San Francisco, CA.ORCID 0000-0001-9287-3375
Seth FrietzeUniversity of Vermont, Department of Biomedical and Health Sciences, Burlington, VT.ORCID 0000-0003-4058-3661

Funding

Vermont INBRE Administrative Supplement 2024 AWD 118P20GM103449 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Julie Dragon · 2012 to 2026
$58.4M
Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI Robert A Koza · 2017 to 2026
$51.6M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
Understanding Ikaros molecular functions for targeted therapies of pre-B ALLR01CA230618 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRIETZE, SETH E, SCHJERVEN, HILDE · 2018 to 2022
$1.8M
Mechanism of Ikaros Tumor Suppression in progenitor B cell leukemiaR21CA209229 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRIETZE, SETH E, SCHJERVEN, HILDE · 2016 to 2017
$420k
Cytek Aurora 5-Laser Spectral Flow CytometerS10OD026940 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SIMOES MARTINS BISPO, CLAUDIA · 2019 to 2019
$341k
NCI NIH HHS R01 CA230618NCI NIH HHS R21 CA209229NIDDK NIH HHS P30 DK063720NIGMS NIH HHS P20 GM103449NIGMS NIH HHS U54 GM115516NIH HHS S10 OD026940
6 · The paper itself

Abstract

B-cell acute lymphoblastic leukemia (B-ALL) is driven by transcriptional dysregulation that impairs B-cell differentiation and sustains leukemic growth. A defining feature of high-risk B-ALL is mutations in

Identifiers

PMID41509392
PMCPMC12776271

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.