Evidence map›Paper›PMID 41509975›Full record

ArticleMaterials today. Bio2026

Multifunctional biofunctionalized hybrid nanoantifungals with novel active coating agents based on cinnamaldehyde- and β-cyclocitral-modified polydopamine.

Maria Paz García-Simarro, Maria Mondéjar-López, Joaquin C García-Martínez, Antonio Cuesta-Casas, Sergio Casas-Tintó, Oussama Ahrazem, Lourdes Gómez-Gómez, Enrique Niza

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria Paz García-SimarroInstituto Botánico. Departamento de Ciencia y Tecnología Agroforestal y Genética. Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain.
Maria Mondéjar-LópezInstituto Botánico. Departamento de Ciencia y Tecnología Agroforestal y Genética. Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain.
Joaquin C García-MartínezUniversidad de Castilla-La Mancha, Departamento de Química Inorgánica, Orgánica y Bioquímica, Facultad de Farmacia, C/ José María Sánchez Ibáñez s/n, 02008, Albacete, Spain.
Antonio Cuesta-CasasUniversidad de Castilla-La Mancha, Departamento de Química Inorgánica, Orgánica y Bioquímica, Facultad de Farmacia, C/ José María Sánchez Ibáñez s/n, 02008, Albacete, Spain.
Sergio Casas-TintóInstitute for Rare Diseases Research, Instituto de Salud Carlos III (ISCIII), 28222 Madrid, Spain.
Oussama AhrazemInstituto Botánico. Departamento de Ciencia y Tecnología Agroforestal y Genética. Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain.
Lourdes Gómez-GómezInstituto Botánico. Departamento de Ciencia y Tecnología Agroforestal y Genética. Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain.
Enrique NizaInstituto Botánico. Departamento de Ciencia y Tecnología Agroforestal y Genética. Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungal pathogens pose serious threats to global agriculture, causing substantial crop loss and food security concerns. Current solutions often rely on conventional pesticides, generating negative environmental impacts. This study presents the development of two novel multifunctional hybrid nanoparticles designed to provide a sustainable alternative for crop protection and growth promotion. These nanoparticles are based on dendritic mesoporous silica nanoparticles (dMSNs) and functionalized with innovative coating agents derived from cinnamaldehyde- (CIN) and β-cyclocitral (βETA) -modified polydopamine (DOPA). The purpose of this research was to create a system that could deliver antifungal agents and support plant development simultaneously, especially under pathogen-induced stress. Nanoparticles exhibited a dual-release mechanism with pH-responsive kinetics, releasing up to 94 % of geraniol (GER) and 81 % of compound βETA, at pH 5. This confirms their ability for targeted, stimulus-triggered delivery. In vitro tests showed strong antifungal activity against several plant pathogenic fungi, with minimum inhibitory concentrations down to 0.078 mg/mL. Microscopic analysis revealed significant disruption of fungal mycelia after treatment, confirming the antifungal mechanism. In vivo biosafety was established through assays on

Indexed as

Advanced nanomaterialsAntifungalCrop protectionpH-responsive releaseSustainable materialsTerpenoids

Identifiers

PMID41509975
PMCPMC12775976

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.