Evidence mapPaperPMID 41510026Full record

ArticleBioinformatics advances2026

Stefan Vocht, Yanren Linda Hu, Andreas Lösch, Kevin Rupp, Tilo Wettig, Lars Grasedyck, Niko Beerenwinkel, Rainer Spang, Rudolf Schill

Abstract read
In one paragraph

Article in Bioinformatics advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stefan VochtDepartment of Statistical Bioinformatics, University of Regensburg, 93053 Regensburg, Germany.
Yanren Linda HuDepartment of Statistical Bioinformatics, University of Regensburg, 93053 Regensburg, Germany.ORCID https://orcid.org/0009-0002-7263-3635
Andreas LöschDepartment of Statistical Bioinformatics, University of Regensburg, 93053 Regensburg, Germany.
Kevin RuppDepartment of Biosystems Science and Engineering, ETH Zürich, 4056 Basel, Switzerland.
Tilo WettigFaculty of Physics, University of Regensburg, 93040 Regensburg, Germany.
Lars GrasedyckInstitute for Geometry and Applied Mathematics, RWTH Aachen, 52056 Aachen, Germany.
Niko BeerenwinkelDepartment of Biosystems Science and Engineering, ETH Zürich, 4056 Basel, Switzerland.ORCID https://orcid.org/0000-0002-0573-6119
Rainer SpangDepartment of Statistical Bioinformatics, University of Regensburg, 93053 Regensburg, Germany.
Rudolf SchillDepartment of Biosystems Science and Engineering, ETH Zürich, 4056 Basel, Switzerland.ORCID https://orcid.org/0000-0003-4649-7190

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Summary: Mutual Hazard Networks (MHNs) are statistical models for analyzing (genetic) cancer progression. Many cancers develop silently and are only noticeable when they have significantly progressed, creating an observational gap until diagnosis. MHNs bridge this gap by reconstructing the underlying dynamics of disease progression. We present mhn, a Python package for dynamic cancer progression analysis using MHNs. It trains an MHN model from tumor genotypes. mhn overcomes challenges of numerical efficiency in model training by making use of Availability and implementation: mhn can be installed from PyPI using pip and is available under the MIT License on GitHub (https://github.com/spang-lab/LearnMHN). Installation instructions and package functionalities are detailed on GitHub and PyPI, with a comprehensive guide on Read the Docs (https://learnmhn.readthedocs.io/en/latest/index.html) and a Jupyter notebook on GitHub to help users explore the package.

Identifiers

PMID41510026
PMCPMC12776348

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.