Evidence map›Paper›PMID 41510234›Full record

ArticleResearch square2025

Macrophage Heterogeneity in Liver Ischemia-Reperfusion Injury.

Yuan Zhai, Yue Wang, Cheng Zhong, Jackson Chin, Nan Xia, Yi-Chu Kao, Tori Huey, Hesham El-Shewy, Dirk Van der Windt, Kris Helke and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuan ZhaiCollege of Medicine, Medical University of South Carolina.ORCID 0000-0003-0485-4022
Yue WangMedical University of South Carolina.
Cheng ZhongMedical University of South Carolina.
Jackson ChinUniversity of california-Los Angeles.
Nan XiaMedical University of South Carolina.
Yi-Chu KaoMedical University of South Carolina.ORCID 0009-0002-8432-6800
Tori HueyMedical University of South Carolina.ORCID 0000-0002-8377-2545
Hesham El-ShewyMedical University of South Carolina.
Dirk Van der WindtMedical University of South Carolina.
Kris HelkeMedical University of South Carolina.ORCID 0000-0001-9746-0764
Thomas MorinelliMedical University of South Carolina.
Aaron MeyerUniversity of California, Los Angeles.ORCID 0000-0003-4513-1840

Funding

Glycogen Synthase Kinase 3 beta in liver ischemia reperfusion injuryR01DK119338 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHAI, YUAN · 2020 to 2023
$1.4M
NIDDK NIH HHS R01 DK119338
6 · The paper itself

Abstract

Kupffer cells (KCs) are implicated in liver ischemia reperfusion injury (IRI). However, their precise roles vs. bone marrow-derived infiltrating macrophages (iMФs) remain controversial. In this study, we used Clec4F-tdTomato (DTR) mice to track KC-specific changes and assessed their function by DT-mediated depletion in the acute phase of liver IRI. We found that liver IR leads to substantial loss of embryonically derived Clec4F

Indexed as

IL-1aIL-1binfiltrating macrophagesKupffer cellsTrem2

Identifiers

PMID41510234
PMCPMC12776437

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.