Evidence map›Paper›PMID 41510289›Full record

ArticleResearch square2025

Coupling the MAPK Slt2/ERK1 Pathway and IRE1-driven UPR Through Transcription Factor Rlm1/MEF2.

Anish Chakraborty, Saswata Chakrabarty, Jagadeesh Kumar Uppala, Kimberly Ann Mayer, Anna J Evans, Jasmine George, Chandrima Ghosh, Ritisha Dey, An Phu Tran Nguyen, Nadege Gouignard and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Anish ChakrabortyDepartment of Biological Sciences, UW-Milwaukee, WI-53211.
Saswata ChakrabartyDepartment of Biological Sciences, UW-Milwaukee, WI-53211.
Jagadeesh Kumar UppalaDepartment of Biological Sciences, UW-Milwaukee, WI-53211.
Kimberly Ann MayerDepartment of Biological Sciences, UW-Milwaukee, WI-53211.
Anna J EvansDepartment of Biological Sciences, UW-Milwaukee, WI-53211.
Jasmine GeorgeDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI-53226.
Chandrima GhoshDepartment of Biological Sciences, UW-Milwaukee, WI-53211.
Ritisha DeyDepartment of Biological Sciences, UW-Milwaukee, WI-53211.
An Phu Tran NguyenDepartment of Biological Sciences, UW-Milwaukee, WI-53211.
Nadege GouignardDepartment of Biological Sciences, UW-Milwaukee, WI-53211.
Pradeep Chaluvally-RaghavanDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI-53226.ORCID https://orcid.org/0000-0002-8268-3460
Madhusudan DeyDepartment of Biological Sciences, UW-Milwaukee, WI-53211.

Funding

Regulating the Unfolded Protein Response in YeastR01GM124183 · NIGMS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI DEY, MADHUSUDAN · 2017 to 2020
$1.3M
Regulators of The Unfolded Protein Response SignalingR15GM159328 · NIGMS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI DEY, MADHUSUDAN · 2025 to 2025
$564k
NIGMS NIH HHS R01 GM124183NIGMS NIH HHS R15 GM159328
6 · The paper itself

Abstract

Unfolded protein response (UPR) is a conserved cellular strategy that enhances the protein folding capacity of cells under stress conditions. In

Indexed as

Endoplasmic reticulum stress (ER stress)Extracellular-signal-regulated kinase (ERK)HAC1 mRNAIRE1 (Inositol requiring enzyme 1)Mitogen-activated protein kinase (MAPK)Protein kinaseSlt2Unfolded protein response (UPR)

Identifiers

PMID41510289
PMCPMC12776503

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.