Patient-specific factors associated with tumour motion in lung stereotactic body radiation therapy from real-time tumour tracking traces.

Background and purpose: Respiratory motion is a major source of geometric uncertainty in lung stereotactic body radiation therapy (SBRT), necessitating individualized motion management. The study aimed to examine the lung tumour motion against patient- and tumour-specific factors. Materials and methods: Motion traces were obtained from 109 retrospective CyberKnife fiducial tracking lung treatments, recorded at 25 Hz through correlation of fiducial and external marker signals. Log files were collected and motion was quantified in the superior-inferior (SI), left-right (LR) and anterior-posterior (AP) directions. Each treatment delivery node (∼2700 per patient) was individually analysed. Clinical data included demographics, comorbidities, prior lung treatments, pulmonary function, and tumour location, size, and histology. Statistical analyses used multivariate and univariate approaches. Results: Tumour location strongly predicted SI motion, with lower lobes showing up to an 8.2 mm greater motion than upper lobes. Previous surgery or radiotherapy moderately reduced LR motion (-0.5 mm), while tumour diameter showed a weak positive association with LR motion (+0.02 mm per mm). Percentage predicted forced expiratory volume in one second (FEV Conclusions: Tumour location primarily determined SI motion, with additional increases linked to better pulmonary function and higher BMI. LR motion was greater in patients without prior lung treatment and with larger tumours, while greater AP motion occurred with better pulmonary function. Lung motion variation was quantified to support sub-millimetre SBRT precision.