Evidence map›Paper›PMID 41511296›Full record

ArticleCells2025

The Knockout of PEX11a Results in Mild Peroxisomal Dysfunction and Lowered Cardiac Recovery Following Langendorff-Mediated Ischemia-Reperfusion in Mice.

Claudia Colasante, Jiangping Chen, Vannuruswamy Garikapati, Bernhard Spengler, Klaus-Dieter Schlüter, Eveline Baumgart-Vogt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Claudia ColasanteInstitute for Anatomy and Cell Biology, Justus Liebig University, Aulweg 123, 35392 Giessen, Germany.ORCID 0000-0002-5760-4919
Jiangping ChenInstitute for Anatomy and Cell Biology, Justus Liebig University, Aulweg 123, 35392 Giessen, Germany.
Vannuruswamy GarikapatiInstitute for Anatomy and Cell Biology, Justus Liebig University, Aulweg 123, 35392 Giessen, Germany.ORCID 0000-0003-1204-349X
Bernhard SpenglerInstitute of Inorganic and Analytical Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.ORCID 0000-0003-0179-5653
Klaus-Dieter SchlüterInstitute for Physiology, Justus Liebig University, Aulweg 129, 35392 Giessen, Germany.ORCID 0000-0002-6093-4919
Eveline Baumgart-VogtInstitute for Anatomy and Cell Biology, Justus Liebig University, Aulweg 123, 35392 Giessen, Germany.ORCID 0000-0002-8265-3763

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peroxisomal biogenesis defects frequently trigger processes of remodeling, increased oxidative stress and metabolic dysregulations that cause cellular dysfunction. Despite extensive research into cardiomyocyte ultrastructure and metabolism, knowledge on peroxisomal function in these cells is scarce. The objective of this study was therefore to investigate the impact of the purportedly asymptomatic (mild) deficiency of the peroxisomal biogenesis protein PEX11a on cardiomyocyte structure and cardiac function in mice. Langendorff-reperfusion experiments revealed diminished post-ischemic recovery following

Indexed as

Membrane ProteinsMyocardial Reperfusion InjuryPeroxisomesAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutMyocytes, CardiacOxidative StressMembrane Proteinscardiomyocyteischemialipid metabolismMALDI imagingoxidative stressperoxisome

Identifiers

PMID41511296
PMCPMC12786121

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.