Evidence map›Paper›PMID 41511304›Full record

ArticleCells2025

Spinal Microglial TLR7 Activation Drives Hyperalgesia in a Lupus Mouse Model via Upregulation of IL-1β, IL-18, and Cav2.2 and Enhanced Glutamatergic Synaptic Activity.

Saumya Bipin, Viacheslav Viatchenko-Karpinski, Catherine Li, Sujin Lim, Han-Rong Weng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Saumya BipinDepartment of Basic Sciences, California Northstate University College of Medicine, 9700 W Taron Drive, Elk Grove, CA 95757, USA.
Viacheslav Viatchenko-KarpinskiDepartment of Biomedical Sciences, Mercer University School of Medicine, Macon, GA 31207, USA.
Catherine LiDepartment of Basic Sciences, California Northstate University College of Medicine, 9700 W Taron Drive, Elk Grove, CA 95757, USA.
Sujin LimDepartment of Basic Sciences, California Northstate University College of Medicine, 9700 W Taron Drive, Elk Grove, CA 95757, USA.
Han-Rong WengDepartment of Basic Sciences, California Northstate University College of Medicine, 9700 W Taron Drive, Elk Grove, CA 95757, USA.ORCID 0000-0003-2062-2782

Funding

Targeting GPR109A for the treatment of pain in systemic lupus erythematosusR01NS107569 · NINDS · UNIVERSITY OF GEORGIA · PI WENG, HAN-RONG · 2018 to 2022
$1.4M
NINDS NIH HHS R01 NS107569
6 · The paper itself

Abstract

Patients with systemic lupus erythematosus (SLE) often suffer from chronic pain due to a lack of effective and safe analgesics. In this study, we investigated the role of spinal TLR7 in the pathogenesis of chronic pain using female

Indexed as

HyperalgesiaInterleukin-18Interleukin-1betaLupus Erythematosus, SystemicMembrane GlycoproteinsMicrogliaSpinal CordToll-Like Receptor 7AnimalsAstrocytesCalcium Channels, N-TypeDisease Models, AnimalFemaleMiceMice, Inbred MRL lprUp-RegulationCacna1b protein, mouseCalcium Channels, N-TypeInterleukin-18Interleukin-1betaMembrane GlycoproteinsTlr7 protein, mouseToll-Like Receptor 7EPSCglial neuronal interactionneuroinflammationnociceptionsynaptic

Identifiers

PMID41511304
PMCPMC12785760

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.