Evidence map›Paper›PMID 41511366›Full record

ArticleCells2026

SOX11 Is Regulated by EGFR-STAT3 and Promotes Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.

Jiayi Peng, Li Cui, Mian Guo, Yi Liu, Wanqi Jia, Kaori Misuno, Jeremy Barrett, Diana Messadi, Shun-Fa Yang, Shen Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiayi PengDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA 90095, USA.
Li CuiDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA 90095, USA.
Mian GuoDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-1475-1935
Yi LiuDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-8420-2157
Wanqi JiaSchool of Biological Sciences, University of California, Irvine, CA 92697, USA.
Kaori MisunoDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA 90095, USA.
Jeremy BarrettDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA 90095, USA.
Diana MessadiDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA 90095, USA.
Shun-Fa YangInstitute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.ORCID 0000-0002-0365-7927
Shen HuDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA 90095, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transcription factor SOX11 is implicated in tumor progression across multiple types of cancers, including head and neck squamous cell carcinoma (HNSCC). However, its mechanistic role in HNSCC remains elusive. In this study, we found that the expression of SOX11 was induced by epidermal growth factor (EGF) but suppressed by an epidermal growth factor receptor (EGFR) inhibitor in HNSCC cells. The signal transducer and activator of transcription 3 (STAT3) bound to the Sox11 gene promoter and transcriptionally upregulated the expression of Sox11 in HNSCC cells. Meanwhile, analyses of The Cancer Genome Atlas (TCGA) gene expression datasets indicated that Sox11 gene expression was significantly overexpressed in HNSCC versus adjacent normal tissues and correlated with those of most epithelial-mesenchymal transition transcription factors (EMT-TFs) and marker genes. Knockdown of SOX11 significantly downregulated the expression of EMT-related genes, including EMT-TFs, vimentin, fibronectin, and N-cadherin, but significantly upregulated E-cadherin and vice versa when SOX11 was overexpressed. Collectively, our studies demonstrated that SOX11 was regulated by EGF-EGFR-STAT3 signals, promoting EMT in HNSCC.

Indexed as

Epithelial-Mesenchymal TransitionHead and Neck NeoplasmsSOXC Transcription FactorsSquamous Cell Carcinoma of Head and NeckSTAT3 Transcription FactorCell Line, TumorEpidermal Growth FactorErbB ReceptorsGene Expression Regulation, NeoplasticHumansSignal TransductionEGFR protein, humanEpidermal Growth FactorErbB ReceptorsSOX11 protein, humanSOXC Transcription FactorsSTAT3 protein, humanSTAT3 Transcription Factorepithelial–mesenchymal transitionhead and neck squamous cell carcinomaSOX11STAT3

Identifiers

PMID41511366
PMCPMC12785246

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.