ArticleNaunyn-Schmiedeberg's archives of pharmacology2026
Fortunellin's dual role in mitigating ferroptosis and neuroinflammation in cerebral ischemia/reperfusion injury.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Ferroptosis and neuroinflammation are critically involved in the progression of cerebral ischemia/reperfusion (I/R) injury. Fortunellin, a citrus flavonoid, has anti-inflammatory and antioxidant benefits. This research was intended to determine the role of fortunellin in ameliorating cerebral I/R injury, focusing on tis dual effects on ferroptosis and neuroinflammation. Undifferentiated PC12 cells were developed into the in vitro model by exposing to oxygen-glucose deprivation/reperfusion (OGD/R). In vivo model was established in Sprague-Dawley (SD) rats via middle cerebral artery occlusion (MCAO). Fortunellin's influence on cerebral I/R injury was analyzed by using CCK8, ELISA, colorimetry, immunofluorescence, behavioral evaluation (sticker removal test and pole test), TTC staining, H&E staining, TUNEL staining and western blot experiments. The mechanism of fortunellin on cerebral I/R injury involved in NF-κB signaling was explored by immunofluorescence and western blot assays. Treatment with fortunellin enhanced viability in OGD/R-injured PC12 cells and lowered the production of TNF-α, IL-6 and IL-1β. In PC12 cells affected by OGD/R, fortunellin increased GPX4 and SLC7A11 expression and decreased Fe
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