Evidence map›Paper›PMID 41511601›Full record

ArticleBulletin of experimental biology and medicine2025

Lung Tissue RNA Sequencing Shows Dysregulation of the Bronchial Epithelium in a Rat Model of Chronic Thromboembolic Pulmonary Hypertension.

N S Vachrushev, A A Karpov, L A Shilenko, D D Vaulina, O V Kalinina, A A Kostareva, M M Galagudza

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

N S VachrushevAlmazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia. drabrikos@gmail.com.
A A KarpovAlmazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
L A ShilenkoAlmazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
D D VaulinaAlmazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
O V KalininaAlmazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
A A KostarevaAlmazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
M M GalagudzaAlmazov National Medical Research Centre, Ministry of Health of the Russian Federation, St. Petersburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied changes in gene expression in rats with chronic thromboembolic pulmonary hypertension (CTEPH) induced by partially biodegradable alginate microspheres. Lung tissue samples were collected 2 and 6 weeks after the last administration of microspheres. Transcriptomic analysis revealed alterations in processes related to the extracellular matrix, cell-cell interactions, and ciliary activity. Histological findings showed thickening of the bronchial walls and increased epithelial thickness; in addition, a higher density of epithelial cells per 50 μm of bronchi was noted at both time points in the CTEPH model. These findings contribute to better understanding of the pathogenesis of lung damage in patients with CTEPH.

Indexed as

BronchiHypertension, PulmonaryLungPulmonary EmbolismAnimalsChronic DiseaseDisease Models, AnimalMaleRatsSequence Analysis, RNAanimal modelbronchichronic thromboembolic pulmonary hypertensionratsRNA sequencing

Identifiers

PMID41511601

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.