Evidence map›Paper›PMID 41511660›Full record

ArticleMolecular biotechnology2026

Berberine Impedes Acute Pancreatitis Development by Suppressing VNN1 Expression and the NF-κB Signaling Pathway.

Jie Yang, Jianjiang Huang, Fang Zhang, Yuyu Wang, Bin Qiu

Abstract read
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In one paragraph

Article in Molecular biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jie YangDepartment of Critical Care Medicine, Shengzhou People's Hospital (Shengzhou Branch of the First Affiliated Hospital of Zhejiang University School of Medicine, the Shengzhou Hospital of Shaoxing University), No. 666, Dangui Road, Shengzhou, 312400, Zhejiang, China. yangjie255@163.com.ORCID http://orcid.org/0009-0009-1810-934X
Jianjiang HuangDepartment of Critical Care Medicine, Shengzhou People's Hospital (Shengzhou Branch of the First Affiliated Hospital of Zhejiang University School of Medicine, the Shengzhou Hospital of Shaoxing University), No. 666, Dangui Road, Shengzhou, 312400, Zhejiang, China.
Fang ZhangDepartment of Critical Care Medicine, Shengzhou People's Hospital (Shengzhou Branch of the First Affiliated Hospital of Zhejiang University School of Medicine, the Shengzhou Hospital of Shaoxing University), No. 666, Dangui Road, Shengzhou, 312400, Zhejiang, China.
Yuyu WangDepartment of Critical Care Medicine, Shengzhou People's Hospital (Shengzhou Branch of the First Affiliated Hospital of Zhejiang University School of Medicine, the Shengzhou Hospital of Shaoxing University), No. 666, Dangui Road, Shengzhou, 312400, Zhejiang, China.
Bin QiuDepartment of Critical Care Medicine, Shengzhou People's Hospital (Shengzhou Branch of the First Affiliated Hospital of Zhejiang University School of Medicine, the Shengzhou Hospital of Shaoxing University), No. 666, Dangui Road, Shengzhou, 312400, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global incidence of acute pancreatitis (AP) is progressively increasing with rising risk factors such as hyperlipidemia and alcoholism. Berberine (BBR), a quaternary ammonium alkaloid and primary antibacterial agent isolated from the traditional Chinese herb, Coptis chinensis, was investigated for its therapeutic mechanisms in AP. Cell viability was first assessed using the MTT assay at various BBR concentrations, with lactate dehydrogenase (LDH) levels measured in parallel. Then, ELISA quantified inflammatory mediators (caspase-1, IL-1β, IL-18, TNF-α, and IL-6), while western blot analyzed pyroptosis markers (NLRP3 and N-GSDMD). ROS and Fe

Indexed as

AmidohydrolasesBerberineNF-kappa BPancreatitisSignal TransductionAnimalsCell LineCell SurvivalCeruletideGPI-Linked ProteinsHumansMolecular Docking SimulationPyroptosisRatsAmidohydrolasesBerberineCeruletideGPI-Linked ProteinsNF-kappa BpantetheinaseAcute PancreatitisBerberineNF-κB Signaling PathwayVanin1

Identifiers

PMID41511660

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.