Evidence map›Paper›PMID 41512017›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Origin of class B J-domain proteins involved in amyloid transactions.

Przemyslaw Domanski, Milena Stolarska, Katarzyna Kalinowska, Dominik Purzycki, Brenda A Schilke, Hubert Wyszkowski, Marcin Pitek, Aneta Szymanska, Katarzyna Bury, Jacek Czub and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Przemyslaw Domanski *Intercollegiate Faculty of Biotechnology, University of Gdansk, Gdansk 80-307, Poland.ORCID 0009-0001-5778-3654
Milena Stolarska *Intercollegiate Faculty of Biotechnology, University of Gdansk, Gdansk 80-307, Poland.ORCID 0000-0002-9428-4213
Katarzyna KalinowskaIntercollegiate Faculty of Biotechnology, University of Gdansk, Gdansk 80-307, Poland.ORCID 0000-0002-1957-304X
Dominik PurzyckiIntercollegiate Faculty of Biotechnology, University of Gdansk, Gdansk 80-307, Poland.ORCID 0009-0003-0389-1136
Brenda A SchilkeDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53726.ORCID 0000-0002-1288-7724
Hubert WyszkowskiIntercollegiate Faculty of Biotechnology, University of Gdansk, Gdansk 80-307, Poland.
Marcin PitekIntercollegiate Faculty of Biotechnology, University of Gdansk, Gdansk 80-307, Poland.ORCID 0000-0002-1300-4364
Aneta SzymanskaFaculty of Chemistry, University of Gdansk, Gdansk 80-308, Poland.ORCID 0000-0002-8664-2041
Katarzyna BuryIntercollegiate Faculty of Biotechnology, University of Gdansk, Gdansk 80-307, Poland.ORCID 0000-0001-8197-1658
Jacek CzubDepartment of Physical Chemistry, Gdansk University of Technology, Gdansk 80-233, Poland.ORCID 0000-0003-3639-6935
Agnieszka A KlosowskaIntercollegiate Faculty of Biotechnology, University of Gdansk, Gdansk 80-307, Poland.ORCID 0000-0001-5295-9473
Elizabeth A CraigDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53726.ORCID 0000-0002-9381-4307
Jaroslaw MarszalekIntercollegiate Faculty of Biotechnology, University of Gdansk, Gdansk 80-307, Poland.ORCID 0000-0002-6978-1189
Bartlomiej TomiczekIntercollegiate Faculty of Biotechnology, University of Gdansk, Gdansk 80-307, Poland.ORCID 0000-0001-9295-663X

Funding

National Science Center, Poland OPUS 21 2021/41/B/NZ8/02835National Science Center, Poland OPUS 27; 2024/53/B/NZ1/00632
6 · The paper itself

Abstract

J-domain protein (JDP) chaperones function widely in proteostasis. Notably, eukaryotic class B JDPs of the cytosol/nucleus prevent assembly or drive disassembly of amyloid aggregates known to cause neurodegenerative diseases, yet their evolutionary origin is not known. Members of the most ubiquitous class B subgroup, canonical B (B

Indexed as

AmyloidEvolution, MolecularMolecular ChaperonesAmino Acid SequenceAnimalsHumansPhylogenyProtein DomainsZinc FingersAmyloidMolecular Chaperonesancestral protein resurrectionconvergent evolutionmolecular chaperonesprotein disaggregationprotein family evolution

Identifiers

PMID41512017
PMCPMC12799103

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.