Evidence map›Paper›PMID 41512864›Full record

ArticleStem cell reports2026

A latent activated olfactory stem cell state revealed by single-cell transcriptomic and epigenomic profiling.

Koen Van den Berge, Dana Bakalar, Hsin-Jung Chou, Divya Kunda, Davide Risso, Kelly Street, Elizabeth Purdom, Sandrine Dudoit, John Ngai, Whitney Heavner

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In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Koen Van den BergeDepartment of Statistics, University of California, Berkeley, Berkeley, CA, USA; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium.
Dana BakalarMolecular Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Hsin-Jung ChouDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Divya KundaMolecular Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Davide RissoDepartment of Statistical Sciences, University of Padova, Padova, Italy.
Kelly StreetDivision of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Elizabeth PurdomDepartment of Statistics, University of California, Berkeley, Berkeley, CA, USA.
Sandrine DudoitDepartment of Statistics, University of California, Berkeley, Berkeley, CA, USA; Division of Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
John NgaiMolecular Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. Electronic address: john.ngai@nih.gov.
Whitney HeavnerMolecular Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. Electronic address: whitney.heavner@nih.gov.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The olfactory epithelium is one of the few regions of the nervous system that sustains neurogenesis throughout life. Its experimental accessibility makes it especially tractable for studying molecular mechanisms that drive neural regeneration in response to injury. In this study, we used single-cell sequencing to identify transcriptional and epigenetic processes involved in determining olfactory epithelial stem cell fate during injury-induced regeneration. By combining gene expression and accessible chromatin profiles of individual lineage-traced olfactory stem cells, we identified transcriptional heterogeneity among activated stem cells at a stage when cell fates are being specified. We further identified a subset of resting cells that appears poised for activation, characterized by accessible chromatin around silent genes prior to their expression in response to injury. These results provide evidence for a latent activated stem cell state in which a subset of quiescent olfactory epithelial stem cells are epigenetically primed to support injury-induced regeneration.

Indexed as

Epigenesis, GeneticEpigenomicsOlfactory MucosaSingle-Cell AnalysisStem CellsTranscriptomeAnimalsCell DifferentiationCell LineageGene Expression ProfilingMiceNeurogenesisSingle-Cell Gene Expression Analysisadult tissue stem cellepigeneticepigenomicshorizontal basal cellneural regenerationneurogenesisolfactoryolfactory epitheliumolfactory stem cellregenerationsingle-cell ATAC-seqsingle-cell RNA-seq

Identifiers

PMID41512864
PMCPMC12903091

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.