Evidence map›Paper›PMID 41513466›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026

Altered Structural Plasticity Mediated by mGlu and NMDA Receptors and Impaired Cognition in a Genetic ASD Model (Shank3

Gerardo Rodrigo Perera-Murcia, Mara Prior-González, Beatriz Gutiérrez-Vera, Violeta Gisselle López-Huerta, Cecilia Gómez-Martínez, Rubén Contreras-López, Luis Tenorio Hernández, Yazmín Ramiro-Cortés

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gerardo Rodrigo Perera-MurciaInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, México.
Mara Prior-GonzálezInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, México.
Beatriz Gutiérrez-VeraInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, México.ORCID 0000-0003-1470-9910
Violeta Gisselle López-HuertaInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, México.
Cecilia Gómez-MartínezInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, México.
Rubén Contreras-LópezInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, México.ORCID 0000-0002-0135-384X
Luis Tenorio HernándezInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, México.
Yazmín Ramiro-CortésInstituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México 04510, México yramiro@ifc.unam.mx.ORCID 0000-0003-1687-0425

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic spine morphology is strongly associated with neurodevelopmental disorders. Synaptic plasticity alters spine volume, a phenomenon known as structural plasticity, which influences information processing within neuronal circuits. Structural changes at dendritic spines are linked to autism spectrum disorders, particularly those involving gene mutations that result in synaptopathy. Loss of a single copy of the

Indexed as

Autism Spectrum DisorderCognitionNerve Tissue ProteinsNeuronal PlasticityReceptors, Metabotropic GlutamateReceptors, N-Methyl-D-AspartateAnimalsDendritic SpinesDisease Models, AnimalFemaleHippocampusMaleMiceMice, Inbred C57BLMice, KnockoutMicrofilament ProteinsMicrofilament ProteinsNerve Tissue ProteinsReceptors, Metabotropic GlutamateReceptors, N-Methyl-D-AspartateShank3 protein, mouseautismdendritic spinesorganotypic culturesSHANK3synaptic plasticitytwo-photon

Identifiers

PMID41513466
PMCPMC12873636

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.