Evidence map›Paper›PMID 41513586›Full record

ArticleCell adhesion & migration2026

Upregulation of LTF promotes left-sided colorectal cancer development via activating PI3K/AKT pathway.

Peng Chen, Mingrui Zhang, Xuefeng Bai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell adhesion & migration, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Peng ChenColorectal Cancer Surgery Ward 1, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
Mingrui ZhangDepartment of Anesthesiology, Chifeng Clinical Medical College Affiliated to Inner Mongolia Medical University, Chifeng, Inner Mongolia, China.ORCID 0009-0009-6669-7019
Xuefeng BaiColorectal Cancer Surgery Ward 1, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.ORCID 0009-0002-5094-7051

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactoferrin (LTF) has gained attention as a potential anti-cancer biomarker, but its role in left-sided colon cancer (LCC) remains poorly understood. This study explores the function of LTF in LCC and its underlying mechanisms. LTF expression was significantly elevated in tumor tissues compared to normal tissues (59.67-fold increase,

Indexed as

Colorectal NeoplasmsLactoferrinPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktUp-RegulationApoptosisCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansNeoplasm InvasivenessPhosphorylationSignal TransductionLactoferrinLTF protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAktlactoferrinLeft-sided colon cancerPI3Kproteomicstumor progression

Identifiers

PMID41513586
PMCPMC12795260

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.