Evidence map›Paper›PMID 41513705›Full record

ArticleScientific reports2026

Hepatitis virus-associated B cell non-Hodgkin's lymphoma involves dysregulated epigenetic and RNA-mediated regulatory gene expression and altered snoRNA transcription.

Amanda N Henning, Myagmarjav Budeebazar, Delgerbat Boldbaatar, Dahgwahdorj Yagaanbuyant, Davaadorj Duger, Khishigjargal Batsukh, Samantha Muccilli, Jordan Pardoe, Lara Perinet, Olivia Conway and 6 more

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

16 authors.

Amanda N HenningDepartment of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA. amanda.henning@nih.gov.
Myagmarjav BudeebazarDepartment of Gastroenterology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
Delgerbat BoldbaatarLiver Center, Ulaanbaatar, Mongolia.
Dahgwahdorj YagaanbuyantLiver Center, Ulaanbaatar, Mongolia.
Davaadorj DugerDepartment of Gastroenterology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
Khishigjargal BatsukhCenter of Hematology and Bone Marrow Transplantation, First Central Hospital of Mongolia, Ulaanbaatar, Mongolia.
Samantha MuccilliDepartment of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Jordan PardoeDepartment of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Lara PerinetDepartment of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Olivia ConwayDepartment of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Darryl Owusu-AnsahDepartment of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Kobe RobichauxDepartment of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Ryan BaumannDepartment of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Harvey J AlterDepartment of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Naranjargal DashdorjLiver Center, Ulaanbaatar, Mongolia.
Valeria De GiorgiDepartment of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA. valeria.degiorgi@nih.gov.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infection with HBV and its satellite virus HDV remain a significant global health issue due to their involvement in hepatic and extrahepatic diseases, including B cell non-Hodgkin's lymphoma (BNHL). Clinical and epidemiological evidence support a causal role for HBV in BNHL development, although mechanistic insight is lacking and the role of HDV infection in this process is unknown. To help elucidate viral drivers of B cell transformation, we performed RNA-sequencing on peripheral B cells from patients with HBV mono-infection, HBV/HDV co-infection, HBV/HDV-associated BNHL, BNHL without viral infection, and healthy donors. In this way, we sought to identify unique and shared transcriptional profiles associated with viral infection and transformation. Our data suggest dysregulated epigenetic and miRNA-mediated regulatory gene expression may be a potential common pathway for lymphomagenesis among viral- and non-viral-associated lymphoma. We also observed wide-spread upregulation of snoRNAs in B cells from virally infected patients, supporting a role for these non-coding RNAs in viral infection and, potentially, viral-associated lymphomagenesis. These results have identified novel areas for future functional studies on the effect of HBV and HDV infection on B cell activity and present additional therapeutic strategies that may benefit both viral- and non-viral associated BNHL.

Indexed as

Hepatitis BHepatitis DLymphoma, B-CellRNA, Small NucleolarAdultAgedB-LymphocytesCoinfectionEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticHepatitis B virusHumansMaleMiddle AgedTranscription, GeneticRNA, Small NucleolarB cell non-Hodgkin’s lymphoma (BNHL)Epigenetic regulationHBV (Hepatitis B Virus)HDV (Hepatitis D Virus)ncRNA (non-coding RNA)snoRNA (small nucleolar RNA)

Identifiers

PMID41513705
PMCPMC12876061

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.