Evidence map›Paper›PMID 41513939›Full record

ArticleScientific reports2026

Opportunistic automated aortic valve calcification assessment in low-cost, screening CT calcium score exams.

Ananya Subramaniam, Hao Wu, Sepideh Azarianpour, Naomi Joseph, Tao Hu, Neda Shafiabadi Hassani, Ammar Hoori, Sanjay Rajagopalan, Sadeer Al-Kindi, David L Wilson

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Ananya SubramaniamDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA. axs1189@case.edu.
Hao WuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Sepideh AzarianpourDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Naomi JosephDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Tao HuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Neda Shafiabadi HassaniHarrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA.
Ammar HooriDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Sanjay RajagopalanHarrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA.
Sadeer Al-KindiCenter for Computational and Precision Health (C3PH), DeBakey Heart and Vascular Center, Houston Methodist, HoustonTX, 77030, USA.
David L WilsonDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA. dlw@case.edu.

Funding

Interdisciplinary Biomedical Imaging Training ProgramT32EB007509 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI DAVID Lynn WILSON, Xin Yu · 2007 to 2026
$5.6M
Cardiovascular risk from comprehensive evaluation of the CT calcium score examR01HL165218 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI Sanjay Rajagopalan, DAVID Lynn WILSON · 2023 to 2026
$3.8M
Pericoronary fat: MACE risk from non-contrast CT and the role of iodine perfusion in contrast CTR01HL167199 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI Sanjay Rajagopalan, DAVID Lynn WILSON · 2023 to 2026
$3.1M
System-independent quantitative cardiac CT perfusionR44HL156811 · NHLBI · BIOINVISION, INC. · PI ROY, DEBASHISH, WILSON, DAVID LYNN · 2021 to 2022
$2.0M
NHLBI NIH HHS R01 HL165218NHLBI NIH HHS R01 HL167199NHLBI NIH HHS R44 HL156811NIBIB NIH HHS T32 EB007509NIH HHS 3R01HL165218-01A1W1NIH HHS R01HL165218
6 · The paper itself

Abstract

Aortic valve stenosis (AS) is the most common valvular disease, with a growing impact in the aging population. AS can culminate in heart failure if left untreated. Early treatment with minimally-invasive transcatheter aortic valve replacement (TAVR) is being evaluated in clinical trials. We addressed an unmet clinical need for early detection, referral to echocardiography for AS evaluation, and possible treatments (e.g., lifestyle changes, drugs, or TAVR). As aortic valve calcification (AVC) is typically present in AS, we created a method to detect AVC in low-cost/no-cost non-contrast CT calcium score (CTCS) screening exam images. We developed a multi-task deep network to identify a cylindrical aortic valve region of interest (ROI) and applied Agatston criteria within the ROI to obtain calcifications. Predicted ROIs had good agreement with cardiologists' labels and sometimes were better, and predicted Agatston scores agreed with cardiologists (r = 1.00, paired t-test p = 0.573, t = 0.57). On a retrospective screening cohort of 2000 + patients, we found that 20.6% of men and 22.2% of women had some degree of AVC. According to guidelines, 3.53% and 9.04%, respectively, would have severe AS. These promising results indicate that further evaluation of this approach is warranted, with the potential for significant public health impact.

Indexed as

Aortic ValveAortic Valve StenosisCalcinosisCalciumTomography, X-Ray ComputedAgedAged, 80 and overFemaleHumansMaleCalciumAortic valve calcificationAortic valve stenosisCT calcium scoreParameter regression

Identifiers

PMID41513939
PMCPMC12868642

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.