ArticleScientific reports2026
Association between serum alpha Klotho levels and the likelihood of abdominal aortic calcification.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
As an anti-aging protein, alpha Klotho (α-Klotho) plays an important role in cardiovascular disease. However, the correlation between α-Klotho and abdominal aortic calcification (AAC) is unclear. The present study explored the relationship between α-Klotho and AAC in US adults. We used data from the National Health and Nutrition Examination Survey (NHANES) 2013–2014 for this cross-sectional study with participants aged 40 years or older, and with complete data on serum α-Klotho levels and AAC scores. And weighted multivariate linear regression and multivariate logistic regression to explore the association between α-Klotho and AAC. A total of 2411 subjects were included in this study. The AAC score for all participants was 1.19 ± 0.07 and the prevalence of severe AAC was 5.85%. In the fully adjusted Model 3, we observed that the AAC score of the highest α-Klotho quartile was 0.71 units lower than the lowest quartile (β = -0.71, 95%CI: -1.25 ~-0.17, p = 0.01) and a 53% lower risk of Severe AAC in the highest α-Klotho quartile than in the lowest quartile (Quartile 4: OR: 0.47, 95% CI: 0.19–0.74, p = 0.01). Interaction terms were also used to test the heterogeneities among each subgroup, and a significant difference was revealed among male, indicating that this association was dependent on gender. In US adults, α-Klotho levels were associated with lower AAC scores and a reduced risk of severe AAC. Future work is needed to confirm these findings and to define any clinical relevance.
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