Evidence map›Paper›PMID 41514036›Full record

ArticleNature medicine2026

The NOTCH3 extracellular domain is a serum biomarker for pulmonary arterial hypertension.

Moises Hernandez, Nolan M Winicki, Cristian D Puerta, Swetha Lakshminarayanan, Yu Zhang, Israel Ramirez-Sanchez, Casandra E Besse, Lin Liu, David S Poch, Jason X-J Yuan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Moises Hernandez *Division of Cardiothoracic Surgery, University of California San Diego, La Jolla, CA, USA.
Nolan M Winicki *Division of Cardiothoracic Surgery, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-0784-2679
Cristian D Puerta *Division of Cardiothoracic Surgery, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-0953-0150
Swetha LakshminarayananDivision of Cardiothoracic Surgery, University of California San Diego, La Jolla, CA, USA.ORCID 0009-0003-7518-4668
Yu ZhangDivision of Cardiothoracic Surgery, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-9172-9301
Israel Ramirez-SanchezDivision of Cardiothoracic Surgery, University of California San Diego, La Jolla, CA, USA.
Casandra E BesseDivision of Cardiothoracic Surgery, University of California San Diego, La Jolla, CA, USA.
Lin LiuDivision of Biostatistics and Bioinformatics, Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA.
David S PochDivision of Pulmonary Medicine, University of California San Diego, La Jolla, CA, USA.
Jason X-J YuanUniversity of Florida Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL, USA.
John Y-J ShyyInstitute of Engineering in Medicine, University of California San Diego, La Jolla, CA, USA.
Paul B YuDivision of Cardiology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-2145-4944
Joe G N GarciaUniversity of Florida Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL, USA.
Patricia A ThistlethwaiteDivision of Cardiothoracic Surgery, University of California San Diego, La Jolla, CA, USA. pthistlethwaite@health.ucsd.edu.ORCID 0000-0002-1986-7304

Funding

Novel Involvement of NAMPT and TLR4 in PAH Vascular RemodelingR01HL141387 · NHLBI · UNIVERSITY OF FLORIDA · 2022 to 2025
$1.3M
NOTCH3 ECD as a Serum Biomarker for Pulmonary Arterial HypertensionR01HL169861 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$614k
NHLBI NIH HHS K08 HL079943NHLBI NIH HHS R01 HL119543NHLBI NIH HHS R01 HL132225NHLBI NIH HHS R01 HL141387NHLBI NIH HHS R01 HL159443NHLBI NIH HHS R01 HL169861U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL119543U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL132225
6 · The paper itself

Abstract

New biomarkers are needed to detect and follow individuals with World Health Organization group 1.1 pulmonary hypertension (idiopathic pulmonary arterial hypertension (IPAH)). As NOTCH3 cleavage occurs constitutively in the lungs of individuals with IPAH, we investigated whether the NOTCH3 extracellular domain (NOTCH3-ECD) shed into serum could be used as a robust biomarker for IPAH. In three geographically distinct cohorts comprising 341 individuals with IPAH (267 women, 74 men) and 376 healthy individuals (278 women, 98 men), serum NOTCH3-ECD levels were significantly higher in individuals with IPAH (mean ± s.d.: 19.9 ± 5.5 ng ml

Indexed as

BiomarkersFamilial Primary Pulmonary HypertensionHypertension, PulmonaryReceptor, Notch3AdultFemaleHumansMaleMiddle AgedPrognosisProtein DomainsROC CurveBiomarkersNOTCH3 protein, humanReceptor, Notch3

Identifiers

PMID41514036
PMCPMC12823441

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.