ArticleBMC public health2026
Circadian syndrome, not metabolic syndrome, is a significant predictor of mild cognitive impairment in middle-aged and older adults - The CHARLS survey during 2015-2018.
Article in BMC public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Non-traditional metabolic indices predict incident circadian syndrome in middle-aged and older Chinese adults: a nationwide prospective cohort study and machine learning analysis.Lipids in health and disease · 2026Observational
- Association of Circadian Syndrome with Incident Risk of 23 Site-Specific Cancers: A Large-Scale Prospective Study in the UK Biobank.Research (Washington, D.C.) · 2026Article
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8 authors.
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Abstract
introductionCircadian syndrome (CircS) and metabolic syndrome (MetS) are thought to potentially affect cognitive function. We aimed to investigate the association between CircS/MetS and mild cognitive impairment (MCI).
methodsData was from two waves of the 2015 and 2018 China Health and Retirement Longitudinal Study. MetS defined by a harmonized standard, while CircS add depression and short sleep duration on MetS. Aging-related cognitive decline is used to define MCI. Next, participants without MCI at baseline were followed for 3 years. Multivariable linear regression and multiple logistic regression were used for the assessment. Finally, we further analyzed the association between CircS/MetS components and MCI.
resultsIn the cross-sectional study (N = 11,719), CircS was associated with lower cognitive scores (β = -0.04, P < 0.001) and higher risk of MCI (OR = 1.02, 95% CI: 1.00-1.04, P < 0.05). MetS was not associated with either cognitive scores or MCI (P > 0.05). In the longitudinal study (N = 8818), CircS increased the risk of MCI by 1.02-fold (95% CI:1.01–1.04, P < 0.05), and MetS still did not show an association with MCI (P > 0.05). In individual component analysis, short sleep (2015 ~ OR = 1.04, 95%CI: 1.02–1.05, P < 0.001) and depression (2015 ~ OR = 1.04, 95%CI: 1.03–1.06, P < 0.001; 2018 ~ OR = 1.03, 95%CI:1.01–1.05, P < 0.01) were associated with a higher risk of MCI.
conclusionCircS is a risk factor for MCI in middle-aged and older adults, serving as a strong predictor of MCI, not MetS.
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