Evidence map›Paper›PMID 41514444›Full record

ReviewMolecular cancer2026

Unlocking the power of non-coding RNAs: toward real-time cancer monitoring in precision oncology.

Manon Chang, Thomas Papazyan, Elvire Pons-Tostivint, Delphine Fradin

Abstract readReview
In one paragraph

Review in Molecular cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. CircPRKCA Promotes NSCLC Progression via miR-200b-3p/FRMD6/SNAI2 Axis.International journal of molecular sciences · 2026
    Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Manon Chang *Nantes Université, Inserm UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.
Thomas Papazyan *Nantes Université, Inserm UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.
Elvire Pons-Tostivint *Nantes Université, Inserm UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France.
Delphine Fradin *Nantes Université, Inserm UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, Nantes, France. delphine.fradin@inserm.fr.

Funding

Fondation ARC pour la Recherche sur le Cancer 4ème année de thèseInstitut National de la Santé et de la Recherche Médicale Poste d'accueil
6 · The paper itself

Abstract

Precision oncology has transformed cancer care by tailoring treatments to individual molecular profiles, but many patients still fail to benefit from current therapies. In this context, biomarkers, particularly those measurable in non-invasive liquid biopsies, offer a promising path toward more effective and dynamic therapeutic strategies. Traditionally, circulating tumor DNA (ctDNA) has guided therapeutic decisions, but its limitations in capturing tumor complexity are becoming increasingly apparent. Conversely, non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are emerging as powerful biomarkers due to their stability in all body fluids and their dynamic regulation in response to treatment. Encapsulated in extracellular vesicles (EVs) or associated with protein/lipid complexes, circulating ncRNAs are released by both tumor and microenvironmental cells, offering a unique biological insight. This review highlights the unique potential of ncRNAs as longitudinal biomarkers for monitoring therapeutic responses, detecting recurrence, and personalizing cancer management in real time, marking the beginning of a new era in precision oncology.

Indexed as

Biomarkers, TumorNeoplasmsPrecision MedicineRNA, UntranslatedAnimalsHumansLiquid BiopsyMicroRNAsBiomarkers, TumorMicroRNAsRNA, UntranslatedBiomarkersCancercircRNAsLiquid biopsylncRNAsmiRNAsMonitoringNon coding RNAsTherapy responseTreatment resistance

Identifiers

PMID41514444
PMCPMC12911194

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.