ArticleCancers2025
Potential of Higher Resolution Synchrotron Radiation Tomography Using Crystal Analyzer-Based Imaging Techniques for Differential Diagnosis of Human Lung Cancers.
Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
backgroundConventional absorption-based computed tomography has a limited ability to resolve lung microarchitectures that are critical for histological subtype discrimination. This study evaluated the potential of X-ray Dark-Field Imaging Computed Tomography (XDFI CT) using synchrotron radiation for non-destructive, three-dimensional visualization of human lung cancer microstructures.
methodsSurgically resected human lung cancer specimens (
resultsSynchrotron radiation XDFI CT enabled clear visualization of normal distal lung microanatomy, including alveolar walls and associated vascular structures, which served as internal references adjacent to tumor regions. Distinct microstructural features-such as invasive growth patterns, fibrotic or keratinized stroma, necrosis, and treatment-related remodeling-were identifiable and varied according to histological subtype. Tumor-normal tissue transitional zones were consistently delineated in all specimens.
conclusionsSynchrotron radiation XDFI CT provides high-resolution, non-destructive volumetric imaging of lung cancer tissues and reveals subtype-associated microarchitectural features. This technique may complement conventional histopathology by enabling three-dimensional virtual histologic assessment of lung cancer specimens.
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