Evidence map›Paper›PMID 41514859›Full record

ArticleBiology2025

Hepatoprotective Effects and Antioxidant Properties of a Herbal Detoxifying Formula Against Chlorpyrifos-Induced Toxicity in Sprague-Dawley Rats.

Phraepakaporn Kunnaja, Sunee Chansakaow, Weerakit Taychaworaditsakul, Supaporn Intatham, Kanjana Jaijoy, Absorn Wittayapraparat, Pedcharada Yusuk, Ratchuporn Suksathan, Seewaboon Sireeratawong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Detoxifying Effects of a Phenolic-RichInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Phraepakaporn KunnajaDepartment of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0001-9499-5114
Sunee ChansakaowDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Weerakit TaychaworaditsakulDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0001-5547-2230
Supaporn IntathamDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Kanjana JaijoyMcCormick Faculty of Nursing, Payap University, Chiang Mai 50000, Thailand.
Absorn WittayapraparatHighland Research and Development Institute (Public Organization), Chiang Mai 50200, Thailand.
Pedcharada YusukHighland Research and Development Institute (Public Organization), Chiang Mai 50200, Thailand.
Ratchuporn SuksathanQueen Sirikit Botanic Garden, The Botanical Garden Organization, Chiang Mai 50180, Thailand.ORCID 0000-0003-1884-727X
Seewaboon SireeratawongDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

Funding

the Highland Research and Development Institute (public organization) 19/2562
6 · The paper itself

Abstract

Chlorpyrifos (CPF), a widely used organophosphate pesticide, induces hepatotoxicity primarily through oxidative stress, acetylcholinesterase (AChE) inhibition, and inflammatory responses. This study evaluated the hepatoprotective potential of detoxifying formulations prepared from four medicinal plants,

Indexed as

antioxidantapoptosischlorpyrifosdetoxifying formulaEmbelia sessiliflorahepatic stellate cellshepatoprotectionrosmarinic acidThunbergia laurifolia

Identifiers

PMID41514859
PMCPMC12785014

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.