ReviewBiology2025
Exercise Ameliorates Immunosenescence: From Mechanisms to Interventions.
Review in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is an inevitable biological process that affects the function of various organs, including the immune system. Immunosenescence is characterized by diminished immune cell function, weakened immune responses, and imbalances in immune components, which together reduce the body's resistance to pathogens and increase the risk of age-related diseases in older adults. These conditions pose direct threats to health and significantly impact quality of life and longevity. Therefore, effective strategies to delay aging and maintain immune function are critical areas of research. Emerging evidence suggests that moderate physical activity can significantly enhance immune system functionality, serving as an effective intervention for mitigating immunosenescence. Exercise is known to remodel the metabolism of carbohydrates, fats, and proteins, strengthen communication between organs and the immune system, regulate the functions of both innate and adaptive immune cells, and decrease age-related chronic inflammation. Furthermore, exercise aids in restoring the functionality of aging immune cells through mechanisms such as autophagy activation, mitochondrial optimization, and epigenetic reprogramming. Importantly, a dose-response relationship exists between various exercise modalities and the attenuation of immunosenescence in older adults, with the cumulative amount of lifelong physical activity profoundly influencing the pace of immunosenescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.