Evidence map›Paper›PMID 41515173›Full record

ArticleNutrients2025

Oral Administration of Astrocyte-Targeted Natural Antioxidants Suppress NOX4-Driven Neuroinflammation and Restore Hippocampal Neurogenesis in MPTP-Induced Parkinson's Disease Mouse Model.

Miri Jo, Chae-Young Kim, Kayoung Ko, Seohee Choi, Jinhye Kim, Kyuhee Park, Isaac Jinwon Yi, Sang-Seop Nahm, Kiyoung Kim, Woosuk Kim and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Miri JoBK21 Four Program, Department of Medical Sciences, Soonchunhyang University, Asan 31538, Republic of Korea.
Chae-Young KimDepartment of Anatomy, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.
Kayoung KoBK21 Four Program, Department of Medical Sciences, Soonchunhyang University, Asan 31538, Republic of Korea.ORCID 0009-0004-4368-2600
Seohee ChoiBK21 Four Program, Department of Medical Sciences, Soonchunhyang University, Asan 31538, Republic of Korea.
Jinhye KimCentral Lab, iCONNECTOME Co., Ltd., Suwon 16229, Republic of Korea.
Kyuhee ParkGyeonggi Business & Science Accelerator, Suwon 16229, Republic of Korea.
Isaac Jinwon YiNeuroscience and Behavioral Biology Program (NBB), College of Arts and Sciences, Emory University, Atlanta, GA 30322, USA.
Sang-Seop NahmDepartment of Anatomy, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.
Kiyoung KimBK21 Four Program, Department of Medical Sciences, Soonchunhyang University, Asan 31538, Republic of Korea.ORCID 0000-0002-4879-5207
Woosuk KimDepartment of Anatomy, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.ORCID 0000-0003-4752-2810
Sun-Shin YiDepartment of Anatomy, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.ORCID 0000-0001-8568-0954

Funding

Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries RS-2024-00400380National Research Foundation of Korea RS-2024-00344269National Research Foundation of Korea RS-2024-00349668
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AntioxidantsAstrocytesHippocampusNADPH Oxidase 4NeurogenesisNeuroinflammatory DiseasesParkinson DiseasePlant ExtractsAdministration, OralAnimalsDisease Models, AnimalDoublecortin ProteinMaleMiceMice, Inbred C57BLOxidative StressAntioxidantsDcx protein, mouseDoublecortin ProteinNADPH Oxidase 4Nox4 protein, mousePlant Extracts1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)astrocytenatural antioxidantsneurogenesisneuroinflammationNOX4oral administrationParkinson’s diseasePassiflora incarnata L. (PI)redox signalingsaffron-derived antioxidant (SDA)

Identifiers

PMID41515173
PMCPMC12787697

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.